Completed
Phase 4
Age: 18Years +
All Genders
ID00447018
Equimolar Doses of Mannitol and Hypertonic Saline in the Treatment of Elevated Intracranial Pressure
Led by University Hospital, Grenoble · Updated on 2007-03-13
20
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
The purpose of this study is to determine whether mannitol is as effective as hypertonic saline solution in the treatment of elevated intracranial pressure in patients with brain injury.
CONDITIONS
Brief Title
Mannitol Versus Hypertonic Saline Solution in the Treatment of Elevated Intracranial Pressure
Who Can Participate
Age: 18Years +
All Genders
Eligibility Criteria
Inclusion Criteria:
- age 18 or older
- sustained elevated intracranial pressure to more than 20 mmHg for more than 10 min
- mechanically ventilated in stable conditions for more than 2 hours prior to the study
- serum osmolality ranged between 280 and 320 mOsm/kg
Exclusion Criteria:
- imminent cranial or extracranial surgery
- leakage or drainage of cerebral spinal fluid
- unstable respiratory and hemodynamic conditions
- oliguric renal failure
- anemia
- use of mannitol or HSS in the previous 6 hours
- concomitant use of thiopentone
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