Status:
COMPLETED
Combined Effects of Nutritional and Exercise Countermeasures
Lead Sponsor:
University of Arkansas
Conditions:
Muscular Atrophy
Muscle Weakness
Eligibility:
All Genders
18-50 years
Phase:
NA
Brief Summary
The purpose of this study is to see if a combination of resistance exercises and amino acid capsules can reduce muscle loss and maintain muscle function during bedrest. This experiment will imitate ma...
Eligibility Criteria
Inclusion
- 18-50 years of age
- Availability of transport and ability to report to Research Center at appointed times
Exclusion
- Subjects with limiting or unstable angina or a cardiology confirmed ECG which demonstrates cardiac abnormalities such as \> 0.2 mV horizontal or downsloping ST segment depression, frequent arrhythmia's (\>10 PVC/min), or valvular disease.
- Subjects with vascular disease as determined by a combination of risk factors of peripheral atherosclerosis, namely hypertension, obesity, diabetes, hypercholesterolemia and/or evidence of venous or arterial insufficiency upon palpitation of femoral, popliteal, and pedal arteries.
- Any history of hypo- or hyper-coagulation disorders including subjects taking Coumadin or with a history of DVT or PE at any point in their lifetime.
- Any subject that has a chronically elevated systolic pressure \>170 or a diastolic blood pressure \> 100 will be excluded. Subjects may be included if they are taking blood pressure medication and have a blood pressure below these criteria.
- Any subject with an uncontrolled metabolic disease including liver or renal disease.
- Fasting blood glucose of \>126 mg/dl on two separate occasions
- Presence of acute illness or metabolically unstable chronic illness.
- Any subject currently on weight-loss diet.
- Inability to abstain from smoking for duration of study.
- Recent ingestion of anabolic steroids (within 6 months).
- Subjects with atrial fibrillation, history of syncope, angina or congestive heart failure.
- Subjects with a recently (6 months) treated cancer other than Basal Cell Carcinoma.
- Pregnancy/lactation.
- Any other condition or event considered exclusionary by the PI and covering faculty
Key Trial Info
Start Date :
January 1 2007
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
June 1 2009
Estimated Enrollment :
31 Patients enrolled
Trial Details
Trial ID
NCT00447044
Start Date
January 1 2007
End Date
June 1 2009
Last Update
June 19 2009
Active Locations (1)
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1
University of Arkansas for Medical Sciences
Little Rock, Arkansas, United States, 72205