Status:
COMPLETED
Reorganization of Brain Functions in Patients With Cervical Myelopathy Using fMRI and MRS
Lead Sponsor:
London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Collaborating Sponsors:
The Physicians' Services Incorporated Foundation
American Association of Neurological Surgeons
Conditions:
Spinal Cord Diseases
Eligibility:
All Genders
18-75 years
Brief Summary
Decompressive surgery to relieve symptoms of spinal cord compression due to dysfunction, such as arthritis, has proved variable in success. Past research has reported that approximately one-third of s...
Detailed Description
Degenerative arthritis is a universal concomitant of human aging, affecting 51% of the adult population. Arthritis of the spine is the most common cause of acquired spinal cord dysfunction and can man...
Eligibility Criteria
Inclusion
- All Participants will be
- between 18 and 75 years of age
- right handed
- with normal/corrected hearing and vision
- native speakers of Canadian or American English
- must be competent to give consent.
- Cervical Myelopathy Patients will be:
- Undergoing a first time cervical decompression for cervical spondylosis causing myelopathy secondary to spinal cord compression which is documented by a diagnostic procedure ( CT and/or MRI ).
- Spinal cord compression from the cervicomedullary junction to the C7-T1 disc level.
- Ability and willingness to participate in a follow-up fMRI study at 6 months following surgery.
- Healthy Control Volunteers will be:
- Volunteers from the Dept. of Clinical Neurological Sciences
Exclusion
- Cervical Myelopathy Patients must not:
- 1\. have any pre-existing medical conditions (e.g. significant renal or hepatic disease)
- Healthy control volunteers must not:
- 1\. have a pre-existing diagnosis or history of a neurological disorder.
- All participants must not:
- 1\. have any potential magnetic metal fragments in their body except for titanium implants placed at the time of surgery will be excluded. Dental work is non-magnetic and does not require participant exclusion.
- Participants who fall into the following categories will not be tested in the 4T scanner:
- claustrophobia
- pacemaker or other electronic implants
- being a welder or soldier
- having been injured by a metallic object that was not removed
- being pregnant or trying to conceive
- women of childbearing potential who are not using an effective method of contraception
- cerebral aneurysm clips.
Key Trial Info
Start Date :
September 1 2008
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
August 1 2012
Estimated Enrollment :
35 Patients enrolled
Trial Details
Trial ID
NCT00447343
Start Date
September 1 2008
End Date
August 1 2012
Last Update
August 28 2017
Active Locations (1)
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1
London Health Sciences Center
London, Ontario, Canada, N6A 5A5