Status:
COMPLETED
Cigarette Smoke and Susceptibility to Influenza Infection
Lead Sponsor:
University of North Carolina, Chapel Hill
Collaborating Sponsors:
Hamner Institutes for Health Sciences
National Institutes of Health (NIH)
Conditions:
Healthy
Eligibility:
All Genders
18-35 years
Brief Summary
This study will be a descriptive comparison of the effects of live attenuated influenza virus (FluMist) on nasal inflammation and oxidative stress in healthy young adults who are not exposed to smoke ...
Detailed Description
Epidemiologic evidence supports a significant relationship between passive cigarette smoke exposure and increased risk for viral respiratory illnesses. Published and preliminary data suggest that airb...
Eligibility Criteria
Inclusion
- age 18-35 years
- healthy nonsmoking who are rarely exposed to SHS OR smokers
Exclusion
- pregnancy or nursing;
- history of egg allergy;
- aspirin therapy;
- asthma;
- immunodeficiency (HIV or other);
- on immunosuppressive drugs including corticosteroids;
- history of Guillain-Barre Syndrome;
- any chronic medical condition;
- febrile and/or respiratory illness within past 3 weeks prior to entry into study;
- prospective subjects with high baseline antibody titers against influenza will be excluded because they may be less likely to develop viral replication with LAIV.
Key Trial Info
Start Date :
July 1 2006
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
September 1 2011
Estimated Enrollment :
138 Patients enrolled
Trial Details
Trial ID
NCT00448617
Start Date
July 1 2006
End Date
September 1 2011
Last Update
May 29 2015
Active Locations (1)
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1
UNC Center for Environmental Medicine, Asthma and Lung Biology
Chapel Hill, North Carolina, United States, 27599-7310