Status:
COMPLETED
Nitrate and Hypertension in Heart Transplanted Patients
Lead Sponsor:
University of Zurich
Conditions:
Hypertension
Heart Transplantation
Eligibility:
All Genders
18-80 years
Phase:
PHASE4
Brief Summary
The aim of the study was to evaluate the acute effect of nitroglycerine infusion on blood pressure and heart rate in heart-transplanted patients with cyclosporine-induced hypertension.
Detailed Description
Background: Cyclosporine represents a milestone in immunosuppression after organ transplantation. Its use, however, comes at the cost of significant side effects, such as arterial hypertension. Our ai...
Eligibility Criteria
Inclusion
- Inclusion Criteria:
- Heart-transplanted group:
- Patients with hypertension and treated with cyclosporine
- Patients under optimal standard therapy
- Patients giving written informed consent
- Control group:
- Patients with hypertension
- Patients without prior transplantation of any kind
- Patients giving written informed consent
- Exclusion criteria:
- Hypertensive patients receiving immunosuppressive drugs
- Patients receiving any kind or nitrate derivates
Exclusion
Key Trial Info
Start Date :
January 1 2003
Trial Type :
INTERVENTIONAL
End Date :
December 1 2004
Estimated Enrollment :
20 Patients enrolled
Trial Details
Trial ID
NCT00449059
Start Date
January 1 2003
End Date
December 1 2004
Last Update
March 19 2007
Active Locations (1)
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1
University Hospital of Zurich
Zurich, Switzerland, CH8091