Status:
COMPLETED
Effect of Conjugated Linoleic Acid Intake on Liver and Kidney Function
Lead Sponsor:
Wageningen University
Collaborating Sponsors:
VU University of Amsterdam
Conditions:
Healthy
Eligibility:
All Genders
18-60 years
Phase:
NA
Brief Summary
The knowledge of the health effects of CLA on the human body is limited. However, CLA supplements are sold over the counter in several countries and various techniques are used to increase the content...
Detailed Description
Each volunteer receives CLA enriched products for a total of 3 weeks containing approximately 20g CLA per day. A control group is not needed. If three subjects or more show one or more blood values fo...
Eligibility Criteria
Inclusion
- age 18-60 years
- serum total cholesterol \< 8.0 mmol/L
- serum triglycerides \< 3.0 mmol/L
- ALAT \< 45 IU/L
- ASAT \< 41 IU/L
- amylase 35-130 U/L
- alkaline phosphatase 40-125 U/L
- bilirubin \< 17 µmol/L
- gamma-glutamyltranspeptidase \> 75 U/L (men) and \< 40 U/L (women)
- lactate dehydrogenase 230-485 U/L
- creatinine clearance \>= 90 mL/min
- fasting glucose levels 70-115 mg/dL
- fasting insulin levels 5-30 mU/L
Exclusion
- use of cholesterol lowering medication
- high alcohol intake
- BMI \> 30
- chronic diseases (such as diabetes, cardiovascular disease, kidney and liver dysfunction)
- pregnancy
Key Trial Info
Start Date :
March 1 2007
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
June 1 2007
Estimated Enrollment :
20 Patients enrolled
Trial Details
Trial ID
NCT00449462
Start Date
March 1 2007
End Date
June 1 2007
Last Update
July 6 2007
Active Locations (2)
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1
VU University Amsterdam, Institute for Health Sciences
Amsterdam, Netherlands
2
Wageningen University, Division of Human Nutrition
Wageningen, Netherlands