Status:
COMPLETED
Improving Vitamin D Status In Cystic Fibrosis
Lead Sponsor:
Atlanta VA Medical Center
Collaborating Sponsors:
Emory University
Conditions:
Cystic Fibrosis
Eligibility:
All Genders
18-60 years
Phase:
NA
Brief Summary
The purpose of this study is to establish an effective method to correct vitamin D deficiency in subjects with cystic fibrosis. The investigators will examine cholecalciferol, ergocalciferol and UV li...
Detailed Description
Hypothesis of this study: Our hypothesis is that other methods such as cholecalciferol replacement and/or low dose ultraviolet radiation to the skin may be more effective in raising serum 25-hydroxyvi...
Eligibility Criteria
Inclusion
- Subjects seen initially at the Emory CF center between the months of September and December
- Age \> 16, both males and females, confirmed cystic fibrosis by genetic testing or sweat testing, FEV1 \> 40%.
Exclusion
- History of lung transplant or awaiting lung transplantation
- Current hospitalization or greater than 6 hospitalizations/year
- History of malignancy, renal disease (calculated GFR \< 50% reduced from normal), liver disease (AST or AST \> 3 times upper limit of normal), greater than 10 mg of prednisone or equivalent, hypercalcemia
- History of easily burned skin after sunlight exposure, taking medications with may cause photosensitivity
- History of skin cancer or multiple moles or family history of skin cancer
- Moderate to severe vitamin D deficiency (25(OH)D ≤ 15 ng/ml).
Key Trial Info
Start Date :
November 1 2006
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
May 1 2011
Estimated Enrollment :
30 Patients enrolled
Trial Details
Trial ID
NCT00450073
Start Date
November 1 2006
End Date
May 1 2011
Last Update
February 21 2014
Active Locations (1)
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1
Emory CF Center
Atlanta, Georgia, United States, 30322