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Status:

COMPLETED

Sunitinib in Treating Patients With Myelodysplastic Syndromes or Chronic Myelomonocytic Leukemia

Lead Sponsor:

National Cancer Institute (NCI)

Conditions:

Chronic Myelomonocytic Leukemia

de Novo Myelodysplastic Syndromes

Eligibility:

All Genders

18+ years

Phase:

PHASE2

Brief Summary

This phase II trial is studying how well sunitinib works in treating patients with myelodysplastic syndromes or chronic myelomonocytic leukemia. Sunitinib may stop the growth of abnormal cells by bloc...

Detailed Description

OBJECTIVES: I. Determine the overall response rate (complete response, partial response, or hematological improvement) in patients with intermediate-2 or high-risk myelodysplastic syndromes or chroni...

Eligibility Criteria

Inclusion

  • MDS syndromes meeting 1 of the following: Intermediate-2 disease, high-risk disease (IPSS score\>=1.5)
  • CMML: WBC\>12,000/mm\^3, Intermediate-2 disease with WBC=\<12,000/mm\^3, high-risk disease (IPSS score\>=1.5) with WBC=\<12,000/mm\^3
  • Patients with insufficient/inadequate metaphases for cytogenetic analysis are eligible if bone marrow blasts are \>10% and/or 2-3 cytopenias are present
  • No known brain metastases
  • Life expectancy\>12 weeks
  • ECOG PS 0-2/Karnofsky PS 60-100%
  • Calcium=\<3.0 mmol/L
  • Bilirubin normal
  • AST and ALT=\<2.5 times upper limit of normal
  • Creatinine normal/creatinine clearance\>=60 mL/min

Exclusion

  • No history of significant ECG abnormalities including but not limited to: ventricular arrhythmias (ventricular tachycardia, ventricular fibrillation\>=3 beats in a row); QTc prolongation (i.e.QTc interval\>=500msec)
  • No history of allergic reaction to compounds of similar chemical/biological composition to sunitinib malate
  • No NYHA class III-IV congestive heart failure
  • Patients with history of NYHA class II congestive heart failure who are asymptomatic on treatment are eligible
  • No abdominal fistula/G perforation/intraabdominal abscess within past 28 days
  • No serious cardiovascular disease within past 12 months including: cerebrovascular accident or transient ischemic attack, myocardial infarction, cardiac arrhythmia, stable or unstable angina, symptomatic congestive heart failure, coronary or peripheral artery bypass graft or stenting
  • No pulmonary embolism within past 12 months
  • No uncontrolled hypertension (systolic BP\>=140 mmHg/diastolic BP\>=90 mmHg)
  • No condition impairing ability to swallow/retain sunitinib malate tablets including: GI tract disease resulting in inability to take oral medication, requirement for IV alimentation, prior surgical procedures affecting absorption, active peptic ulcer disease
  • No serious/nonhealing wound, ulcer, or bone fracture
  • No uncontrolled pre-existing thyroid abnormality
  • No concurrent uncontrolled illness including ongoing/active infection
  • No psychiatric illness/social situation that would preclude study participation
  • Not pregnant/nursing
  • Negative pregnancy test
  • Fertile patients must use effective barrier contraception
  • 4 weeks since prior major surgery
  • Prior central thoracic radiotherapy that included heart in radiotherapy port allowed provided NYHA congestive heart failure=\<class II
  • Prior anthracycline exposure allowed provided NYHA congestive heart failure=\<class II
  • No other prior therapy for MDS/CMML except epoetin alfa, darbepoetin alfa, filgrastim or sargramostim
  • At least 2 weeks since prior epoetin alfa
  • At least 4 weeks since prior darbepoetin alfa
  • No other prior antiangiogenic agents including but not limited to: bevacizumab, sorafenib tosylate, pazopanib hydrochloride, AZD2171, vatalanib, VEGF Trap
  • More than 7 days since prior and no concurrent potent CYP3A4 inhibitors
  • More than 12 days since prior and no concurrent potent CYP3A4 inducers including: Rifampin, Rifabutin, Carbamazepine, Phenobarbital, Phenytoin, Hypericum perforatum, Efavirenz, Tipranavir
  • No concurrent birth control patch/oral birth control pills/depot/injectable birth control methods
  • No concurrent therapeutic coumarin-derivative anticoagulants
  • Low dose(=\<2mg) warfarin for prophylaxis of thrombosis allowed
  • Low molecular weight heparin allowed if INR=\<1.5
  • No concurrent agents with proarrhythmic potential including: Terfenadine, Quinidine, Procainamide, Disopyramide, Sotalol, Probucol, Bepridil, Haloperidol, Risperidone, Indapamide, Flecainide acetate
  • No concurrent combination antiretroviral therapy for HIV-positive patients
  • No other concurrent investigational agents

Key Trial Info

Start Date :

February 1 2007

Trial Type :

INTERVENTIONAL

Allocation :

ACTUAL

End Date :

October 1 2012

Estimated Enrollment :

10 Patients enrolled

Trial Details

Trial ID

NCT00451048

Start Date

February 1 2007

End Date

October 1 2012

Last Update

September 4 2018

Active Locations (4)

Enter a location and click search to find clinical trials sorted by distance.

Page 1 of 1 (4 locations)

1

Roswell Park Cancer Institute

Buffalo, New York, United States, 14263

2

London Regional Cancer Program

London, Ontario, Canada, N6A 4L6

3

Odette Cancer Centre- Sunnybrook Health Sciences Centre

Toronto, Ontario, Canada, M4N 3M5

4

University Health Network-Princess Margaret Hospital

Toronto, Ontario, Canada, M5G 2M9