Status:
COMPLETED
Botulinum Toxin Injection for the Management of BPH
Lead Sponsor:
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Collaborating Sponsors:
George Washington University
Conditions:
Benign Prostatic Hyperplasia
Eligibility:
MALE
50+ years
Phase:
PHASE2
Brief Summary
This is a double-blind randomized phase II trial to determine whether two different doses of BoNT/A injection into the prostate gland demonstrate sufficient improvement in the management of lower urin...
Eligibility Criteria
Inclusion
- Male at least 50 years of age.
- Voided volume =\> 125 ml.
- Maximum urinary flow \< 15 ml/sec.
- AUA symptom severity score =\> 8.
- Patient signed informed consent prior to the performance of any study procedures.
- Patient able to complete the study protocol in the opinion of the investigator.
Exclusion
- Any prior surgical intervention for BPH.
- Current diagnosis of acute or chronic prostatitis (which may cause LUTS that mimic BPH).
- Overactive bladder without bladder outlet obstruction.
- Enrolled in another treatment trial for any disease within the past 30 days.
- Men interested in future fertility.
- Previous exposure to botulinum toxin.
- On alpha-blocker within the past 48 hours.
- On any 5-alpha-reductase inhibitor within the past month.
- Post void residual \> 350 ml.
- On phenylephrine, pseudoephedrine, imipramine, an anticholinergic, or cholinergic medication within the past 2 weeks.
- On estrogen, androgen, any drug producing androgen suppression, or anabolic steroids within the past 4 months.
- Clinically significant renal or hepatic impairment as determined by abnormal creatinine or AST levels (based on local institutional values).
- Serum prostate specific antigen level \> 8 ng/ml (Hybritech). For those with a PSA between 4-8 ng/ml, the PSA elevation must be considered to be from a benign cause in the opinion of the PI. This decision can be based on PSA velocity, previous TRUS biopsy, percent free PSA, or other clinical estimations in keeping with sound urologic care.
- Active urinary tract disease or biopsy of the prostate within the past 6 weeks.
- Daily use of a pad or device for incontinence required.
- Episode of unstable angina pectoris, myocardial infarction, transient ischemic attack, or cerebrovascular accident (stroke) within the past 6 months.
- On aminoglycosides or any drug that interfere with neuromuscular transmission.
- Eaton-Lambert syndrome, hemophilia, hereditary clotting factors deficiency, or bleeding diathesis.
- Penile prosthesis or artificial urinary sphincter.
- History or current evidence of carcinoma of the prostate or bladder, pelvic radiation or surgery, urethral stricture, or bladder neck obstruction.
- Known primary neurologic conditions such as multiple sclerosis, myasthenia gravis or Parkinson's disease, or other neurological diseases known to affect bladder function.
- Documented bacterial or acute prostatitis within the past year.
- Two documented urinary tract infections of any type in the past year (UTI defined as \> 100,000 colonies per ml urine from midstream clean catch or catheterized specimen).
- History of bladder calculi.
- Patients must be off aspirin, NSAIDS, and Coumadin for 7 or more days prior to botulinum toxin injection.
- Cancer that is not considered cured, except basal cell or squamous cell carcinoma of the skin (cured defined as no evidence of cancer within the past 5 years).
- Any serious medical condition likely to impede successful completion of the study, such as certain mental disorders, hypersensitivity to botulinum toxin or anesthetics used in the study, syncope, uncontrolled diabetes.
Key Trial Info
Start Date :
October 1 2006
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 1 2009
Estimated Enrollment :
134 Patients enrolled
Trial Details
Trial ID
NCT00451191
Start Date
October 1 2006
End Date
December 1 2009
Last Update
April 21 2020
Active Locations (7)
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1
University of Colorado Health Sciences Center
Denver, Colorado, United States, 80010
2
Northwestern University
Chicago, Illinois, United States, 60611
3
Mayo Clinic
Rochester, Minnesota, United States, 55905
4
Cornell University
New York, New York, United States, 10021