Status:
COMPLETED
Effect of GlucoNorm vs Glyburide on Post-Prandial Hyperglycemia in Elderly Subjects With Type 2 Diabetes
Lead Sponsor:
University of British Columbia
Collaborating Sponsors:
Novo Nordisk A/S
Conditions:
Type 2 Diabetes
Eligibility:
All Genders
65+ years
Phase:
PHASE2
Brief Summary
The results from the DECODE Study have shown that postprandial (1 - 2 hours after a meal) hyperglycemia (elevated blood sugar) is more common in elderly people with diabetes than younger people with d...
Detailed Description
The results from the DECODE Study have shown that postprandial hyperglycemia is more common in elderly people with diabetes than younger people and is the best predictor of mortality and morbidity. St...
Eligibility Criteria
Inclusion
- Type 2 diabetes \> 3 months duration
- Male or female
- Over 65 years of age
- Diet controlled only
- HgbA1C \< 8.5%
Exclusion
- Treatment with oral hypoglycemic agents or insulin or the likelihood of requiring treatment with these during the study.
- Anemia - hgb below 130 g/L (males) and below 120 g/L (females).
- Taking medications that known to interfere with glucose metabolism eg systemic corticosteriods, non-selective beta blockers.
- Known or suspected allergy to glyburide, sulfa drugs or GlucoNorm impaired liver function, as shown by but not limited to AST and/or ALT \> 2x the upper limit of normal.
- Impaired renal function, as shown by but not limited to serum creatinine \> 133 µmol/L (males) or 124 µmol/L (females).
- Participated in another clinical trial within the past 30 days.
Key Trial Info
Start Date :
November 1 2003
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
September 1 2011
Estimated Enrollment :
30 Patients enrolled
Trial Details
Trial ID
NCT00451620
Start Date
November 1 2003
End Date
September 1 2011
Last Update
January 18 2018
Active Locations (1)
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1
University of British Columbia
Vancouver, British Columbia, Canada