Status:
COMPLETED
Acamprosate Added to Escitalopram and Behavioral Treatment for Comorbid Depression and Alcoholism
Lead Sponsor:
Massachusetts General Hospital
Collaborating Sponsors:
National Alliance for Research on Schizophrenia and Depression
Conditions:
Major Depressive Disorder
Alcohol Abuse
Eligibility:
All Genders
18-64 years
Phase:
PHASE4
Brief Summary
This is a study about treatment for people who suffer from both major depression and alcohol abuse or dependence. The study will examine whether the addition of acamprosate to escitalopram and behavio...
Detailed Description
Depression and alcohol use disorders contribute to a significant proportion of the burden of disease, in the United States and abroad. Patients who suffer from co-morbid depression and alcohol abuse/d...
Eligibility Criteria
Inclusion
- DSM-IV diagnostic criteria for MDD (diagnosis based on Structured Clinical Interview for DSM-IV, Patient Edition; SCID I/P)
- Written informed consent
- Men and women aged 18-64 years
- Current diagnosis of alcohol abuse/dependence as per SCID I/P
Exclusion
- Subjects with suicidal ideation where outpatient treatment is determined unsafe by the study clinician. These patients will be immediately referred to appropriate clinical treatment.
- Pregnant women or women of childbearing potential who are not using a medically accepted means of contraception (defined as oral contraceptive pill or implant, condom, diaphragm, spermicide, IUD, s/p tubal ligation, partner with vasectomy).
- Known history of serious or unstable medical illness, including cardiovascular, hepatic, renal, respiratory, endocrine, neurologic or hematologic disease.
- History of seizure disorder, brain injury, any history of known neurological disease (multiple sclerosis, degenerative disease such as ALS, Parkinson disease and any movement disorders, etc.).
- Clinical or lab evidence of untreated hypothyroidism.
- History or current diagnosis of the following DSM-IV psychiatric illness: organic mental disorder, schizophrenia, schizoaffective disorder, delusional disorder, psychotic disorders not otherwise specified, bipolar disorder, patients with mood congruent or mood incongruent psychotic features, patients with substance use disorders (excluding alcohol and nicotine) active within the last 12 months.
- Current use of other psychotropic drugs, including current use of benzodiazepines, hypnotics, anticonvulsants. Concomitant use of antihistamine drugs will be allowed. Patients will need to be off all antidepressants for at least two weeks by the time of the baseline visit, and four weeks for fluoxetine, and off benzodiazepines and other psychotropics for at least one week. The decision about whether to taper existing medications should be made by the individual and their primary treater based on clinical care and will not be made for purposes of study enrollment. allowed.
- Patients who have failed to respond during the course of their current major depressive episode to at least two adequate antidepressant trials. An adequate antidepressant trial is defined as six weeks or more of treatment with escitalopram \> 20mg/day or its antidepressant equivalent: (fluoxetine 40mg/day, sertraline \> 100 mg/day, paroxetine \> 40 mg/day, fluvoxamine \> 100 mg/day, citalopram \> 40 mg/day, escitalopram \> 20 mg/day, venlafaxine \> 150 mg/day, and duloxetine \> 60 mg/day).
- Any depression-focused or substance-abuse focused psychotherapy (family or marital counseling would be allowed).
- Patients who have taken an investigational psychotropic drug within the past year.
- Need for medical or inpatient detoxification from alcohol. This determination will be made by the screening clinician, based on clinical judgement as in the multicenter STAR\*D study (PHRC #2000-P-001955 in accordance with methods used in the multi-center STAR-D study.
Key Trial Info
Start Date :
March 1 2007
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
May 1 2010
Estimated Enrollment :
23 Patients enrolled
Trial Details
Trial ID
NCT00452543
Start Date
March 1 2007
End Date
May 1 2010
Last Update
July 9 2012
Active Locations (1)
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1
Massachusetts General Hospital
Boston, Massachusetts, United States, 02114