Status:
COMPLETED
Regulatory T Cells in COPD
Lead Sponsor:
Groningen Research Institute for Asthma and COPD
Conditions:
Chronic Obstructive Pulmonary Disease
Eligibility:
MALE
40+ years
Brief Summary
Lymphoid follicles, consisting of T-and B cells, are involved in the chronic inflammatory response in COPD. Foxp3 positive regulatory T cells (Tregs) are present in these follicles and may be involved...
Detailed Description
COPD is a leading cause of death worldwide and its morbidity and mortality are still rising.So far, no effective treatment is available To find better treatment methods more insight is needed in the n...
Eligibility Criteria
Inclusion
- COPD patients
- Clinical diagnosed COPD
- No allergies
- Post-bronchodilator FEV1 \< 80% predicted, and post-bronchodilator FEV1/FVC \< 70%
- No use of (inhaled) corticosteroids in the 6 weeks preceding the study
- Age \> 40
- Smokers and ex- smokers \> 10 pack years
- Ex-smokers have to have quitted smoking for at least one year
- No other major current health problems
- Informed consent Healthy controls
- No signs of pulmonary disease
- No allergies or hyperreactivity
- No other major current health problems
- FEV1 \> 90 % predicted, FEV1/FVC \> 70%
- Age \> 40
- Never smokers, i.e. no cigarettes last year, and maximal 5 pack years
- Smokers and ex- smokers \> 10 pack years
- Ex-smokers have to have quitted smoking for at least one year
- Informed consent
Exclusion
- Use of (inhaled) corticosteroids in the 6 weeks preceding the study
- Addiction to alcohol or drugs
- COPD exacerbation in the 6 weeks preceding the study
Key Trial Info
Start Date :
January 1 2007
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
November 1 2007
Estimated Enrollment :
50 Patients enrolled
Trial Details
Trial ID
NCT00452764
Start Date
January 1 2007
End Date
November 1 2007
Last Update
November 8 2007
Active Locations (1)
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1
University Medical Center Groningen
Groningen, Netherlands