Status:
COMPLETED
Mechanism of Growth Hormone Effects on Adipose Tissue
Lead Sponsor:
Pennington Biomedical Research Center
Conditions:
Obesity
Eligibility:
MALE
40-70 years
Phase:
PHASE4
Brief Summary
Growth hormone treatment in humans has been shown to decrease body fat. This study aims to determine what adipose tissue depots are affected by GH and what is the mechanism.
Detailed Description
Growth hormone (GH) replacement in GH deficient adults results in an improvement in metabolic status, an increase in lean body mass and a reduction in visceral adiposity. GH might also decrease viscer...
Eligibility Criteria
Inclusion
- Male, aged 40-70
- Central obesity defined as waist circumference greater than 102 cm and BMI \> 27 and \< 35 kg/m2
- No weight loss in last 12 months
- Total IGF-1 level \< 241 ng/ml (\~25th percentile for the assay)
- Body habitus which permitted accurate CT scan acquisition and analysis.
Exclusion
- Significant neurologic, metabolic, endocrine, cardiac, respiratory or gastrointestinal disease
- Diabetes
- Known coronary heart disease
- Exercised more than 3 hours per week
- Unwilling or unable to abstain from alcohol for 72 hours prior to the measurements of energy expenditure and fasting blood work
Key Trial Info
Start Date :
April 1 1999
Trial Type :
INTERVENTIONAL
End Date :
December 1 2000
Estimated Enrollment :
30 Patients enrolled
Trial Details
Trial ID
NCT00453557
Start Date
April 1 1999
End Date
December 1 2000
Last Update
December 8 2016
Active Locations (1)
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1
Pennington Biomedical Research Center
Baton Rouge, Louisiana, United States, 70808