Status:
COMPLETED
Brain Natriuretic Peptide (BNP) Levels in Patients in Non Invasive Mechanical Ventilation
Lead Sponsor:
Ospedale S. Giovanni Bosco
Conditions:
Respiratory Insufficiency
Eligibility:
All Genders
18-90 years
Brief Summary
The purpose of the study is to evaluate variation of BNP in non invasive mechanical ventilated patients with severe acute respiratory failure.
Detailed Description
The aim of the study is to evaluate in patients with severe acute respiratory failure requiring non invasive mechanical ventilation BNP levels at admission and during the following 24 hours during non...
Eligibility Criteria
Inclusion
- Severe respiratory distress (use of respiratory accessory muscles);
- Respiratory rate \> 25 per minute;
- Respiratory acidosis (pH \< 7.35 and PaCO2 \> 45 mmHg);
- PaO2/FiO2 \< 250
Exclusion
- Age \< 18 years;
- Facial deformities;
- Pneumothorax;
- Shock or systolic arterial pressure below 90 mmHg with amine infusion;
- Life-threatening arrhythmias;
- Need for immediate endotracheal intubation (PaO2/FiO2 \< 100 with FiO2 100%, respiratory rate \< 10, GCS \< 8);
- Lack of co-operation from the patient;
- Recent esophageal-gastric surgery;
- Inability to clear secretions;
- Drugs that may interfere with BNP secretion;
- Severe obesity;
- Hepatic cirrhosis with ascitis;
- Endocrine disease.
Key Trial Info
Start Date :
May 1 2006
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
July 1 2009
Estimated Enrollment :
40 Patients enrolled
Trial Details
Trial ID
NCT00453726
Start Date
May 1 2006
End Date
July 1 2009
Last Update
October 5 2009
Active Locations (1)
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1
Ospedale San Giovanni Bosco Medicina d'Urgenza
Turin, Piedmont, Italy, 10154