Status:
COMPLETED
A Study To Investigate The Effect Of Inhaled Fluticasone Propionate On The Bronchial Responsiveness To Leukotriene D4 In Asthmatics Patients
Lead Sponsor:
GlaxoSmithKline
Conditions:
Asthma
Mild Asthma
Eligibility:
All Genders
18-50 years
Phase:
PHASE4
Brief Summary
Investigate if asthmatics treated with FLIXOTIDE (FP) 500 mcg BID during 14 days get reduced bronchial reactivity after inhalation of Leukotriene D4. Two 14 days treatment periods where patients recei...
Eligibility Criteria
Inclusion
- Inclusion:
- Diagnosed history of asthma
- Non smoker last two years
- \< 5 pack years
- FEV1 \>70% of predicted
- Mild and stable asthma
- Only using short acting b2-agonist as rescue for the last 4 weeks
- Have a history of atopy.
- Exclusion:
- Any significant respiratory disease, other than asthma
- Subjects with seasonal asthma may not be included if they are in their season
- Use of oral or inhaled glucocorticosteroid for the last 3 months and long-acting or oral b2-agonists, anticholinergic bronchodilators, cromones, antihistamines, theophyllines and antileukotrienes within two weeks
- Upper or lower RTI within 6 weeks
- Evidence of any disease that in the investigators mind would affect the results of the study
- Participating in another study within 4 weeks
- Females who are pregnant, intend to be or who are lactating
- Methacholine PD20 \> 454mcg
- Negative scin prick test
Exclusion
Key Trial Info
Start Date :
November 1 2002
Trial Type :
INTERVENTIONAL
End Date :
May 1 2004
Estimated Enrollment :
14 Patients enrolled
Trial Details
Trial ID
NCT00453778
Start Date
November 1 2002
End Date
May 1 2004
Last Update
February 12 2013
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