Status:
TERMINATED
Cognitive Protection - Dexmedetomidine and Cognitive Reserve
Lead Sponsor:
Icahn School of Medicine at Mount Sinai
Conditions:
Postoperative Delirium
PD
Eligibility:
All Genders
65+ years
Phase:
PHASE4
Brief Summary
This is a pilot study to evaluate the effect of dexmedetomidine in the prevention of delirium in non-cardiac surgical patients. The preliminary data regarding the effect of dexmedetomidine on delirium...
Detailed Description
Elderly patients who undergo anesthesia and non-cardiac surgery are subject to deterioration of brain function including the development of postoperative delirium (PD) and postoperative cognitive dysf...
Eligibility Criteria
Inclusion
- age 65 years and older
- elective major hip replacement or peripheral vascular (major surgery is defined by a planned 2 day hospitalization)
- ASA physical status I-III
- capable and willing to consent
Exclusion
- Cardiac surgery
- Intracranial Surgery
- Emergency Surgery
- Patients with severe visual or auditory disorder/handicaps
- Illiteracy
- Patients with clinically significant Parkinson's Disease
- Patients not expected to be able to complete the 3 month postoperative test
- Sick sinus syndrome without pacemaker
- Hypersensitivity to drug or class
- Current 2nd or 3rd degree AV block
- History of clinically significant bradycardia
- Contraindication to the use of an 2A-agonist
- Presence of a major psychiatric condition such as bipolar disorder, major depression, schizophrenia, or dementia
- ASA physical status IV or V
Key Trial Info
Start Date :
September 1 2006
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
April 1 2009
Estimated Enrollment :
27 Patients enrolled
Trial Details
Trial ID
NCT00455143
Start Date
September 1 2006
End Date
April 1 2009
Last Update
July 17 2019
Active Locations (1)
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1
Icahn School of Medicine at Mount Sinai
New York, New York, United States, 10029