Status:
UNKNOWN
The Effects of Exercise Versus Inactivity on People With Mitochondrial Muscle Disease
Lead Sponsor:
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Conditions:
Mitochondrial Myopathy
Eligibility:
All Genders
18-65 years
Phase:
PHASE2
Brief Summary
Mitochondrial myopathies include various inherited diseases that are caused by damage to the mitochondria, energy-producing structures that fuel the body's processes. The main symptoms are muscle weak...
Detailed Description
Mitochondrial myopathies are caused by mutant mitochondrial DNA, genetic defects in parts of the mitochondrial DNA. These defects can include missing or deleted DNA that typically codes for certain pr...
Eligibility Criteria
Inclusion
- Diagnosis of mitochondrial myopathy
- Single-large scale deletions of mitochondrial DNA
- Point mutations in mitochondrial DNA
Exclusion
- Symptoms or electrocardiogram-generated signs of coronary artery disease
- Symptoms of congestive heart failure; peripheral vascular disease; or lung, kidney, or liver disease
- History of alcohol or substance abuse
- Metal implants or related devices that contraindicate MRI
- Current use of or require any medications that have significant systemic cardiovascular effects
- Diabetes
- Obesity (body mass index \[BMI\] greater than 30)
- Resting systolic blood pressure greater than 140 mmHg and/or diastolic blood pressure greater than 90 mmHg at three different times
Key Trial Info
Start Date :
June 1 2007
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
June 1 2012
Estimated Enrollment :
50 Patients enrolled
Trial Details
Trial ID
NCT00457314
Start Date
June 1 2007
End Date
June 1 2012
Last Update
May 19 2009
Active Locations (1)
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1
University of Texas Southwestern Medical Center
Dallas, Texas, United States, 75321