Status:
COMPLETED
Does Caffeine Reduce Rosuvastatin-Induced Protection Against Ischemia-Reperfusion Injury?
Lead Sponsor:
Radboud University Medical Center
Conditions:
Ischemia Reperfusion Injury
Eligibility:
MALE
18-50 years
Phase:
PHASE4
Brief Summary
Does caffeine reduce rosuvastatin induced protection against ischemia reperfusion injury?
Detailed Description
Rosuvastatin is a proven cholesterol lowering medicine, which hereby is assumed to achieve a reduction in cardiovascular events. Apart from it's cholesterol lowering action, rosuvastatin may also incr...
Eligibility Criteria
Inclusion
- Male
- age between 18-50 yrs
- signed informed consent
Exclusion
- Cardiovascular disease
- Hypertension (systole \> 140 mmHg, diastole \> 90 mmHg)
- Hypercholesterolemia (fasting total cholesterol \> 6,0 mmol/l)
- Drug abuse
- Concomitant medication use
- Inability to perform the ischemic isometric muscle contraction
- Diabetes Mellitus (fasting glucose \> 7.0 mmol/L or random glucose \> 11.0 mmol/L)
- Alanine-Amino-Transferase (ALAT) \>90U/L (more than twice the upper level of the normal range)
- Creatinine Kinase (CK) \>340U/L (more than twice the upper level of the normal range)
- Participation in any trial concerning medicinal products during the last 60 days prior to this study.
- Participation in clinical trial involving
Key Trial Info
Start Date :
June 1 2007
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
November 1 2007
Estimated Enrollment :
24 Patients enrolled
Trial Details
Trial ID
NCT00457652
Start Date
June 1 2007
End Date
November 1 2007
Last Update
April 15 2008
Active Locations (1)
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1
UMCN st.Radboud
Nijmegen, Netherlands