Status:
COMPLETED
Body Plethysmograph Measurements Before and After Methacholine Challenge in Early Childhood
Lead Sponsor:
Rambam Health Care Campus
Conditions:
Asthma
Eligibility:
All Genders
3-7 years
Brief Summary
In our previous study of Methacholine Challenge Tests (MCT) in preschool children, we found that wheeze detection was associated with significant reduction in flows and vital capacity values. We hypot...
Detailed Description
In young children that cannot perform adequately spirometry methacholine challenge test (MCT) is continued until any of the following clinical signals occurred: appearance of audible wheeze, a fall of...
Eligibility Criteria
Inclusion
- 5-6.9 year-old children who were asthmatic according to GINA guidelines.
- All children previously had recurrent episodes of wheeze, cough and/or shortness of breath with clinical response to bronchodilator.
- Children were included only if they had not received anti-inflammatory medication for at least one week prior to the test or bronchodilators for at least 24 hours prior to the study.
- On the day of testing, children were included if they had normal chest auscultation and FEV1\>75% predicted for healthy preschool children.
Exclusion
- Presence of other chronic respiratory conditions
- Emergency room visit in the past three months
- Respiratory infection in the past month
Key Trial Info
Start Date :
February 1 2006
Trial Type :
OBSERVATIONAL
End Date :
September 1 2006
Estimated Enrollment :
50 Patients enrolled
Trial Details
Trial ID
NCT00458627
Start Date
February 1 2006
End Date
September 1 2006
Last Update
April 11 2007
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