Status:
TERMINATED
Dasatinib in Treating Patients With Advanced Liver Cancer That Cannot Be Removed by Surgery
Lead Sponsor:
National Cancer Institute (NCI)
Conditions:
Adult Primary Hepatocellular Carcinoma
Advanced Adult Primary Liver Cancer
Eligibility:
All Genders
18+ years
Phase:
PHASE2
Brief Summary
This phase II trial is studying how well dasatinib works in treating patients with advanced liver cancer that cannot be removed by surgery. Dasatinib may stop the growth of tumor cells by blocking som...
Detailed Description
PRIMARY OBJECTIVES: I. Determine the progression-free survival (PFS) rate and response rate (complete and partial response) at 4 months in patients with unresectable advanced hepatocellular carcinoma...
Eligibility Criteria
Inclusion
- Criteria:
- WBC \>= 3,000/mm\^3
- LVEF normal
- Histologically or cytologically confirmed hepatocellular carcinoma; Advanced disease, unresectable disease, no Childs C criteria
- Measurable disease, defined as \>= 1 unidimensionally measurable lesion \>= 20 mm by conventional techniques or \>= 10 mm by spiral CT scan
- Not a candidate for percutaneous ethanol injection or radiofrequency ablation (RFA)
- Prior transarterial chemoembolization, ethanol, and RFA allowed if new lesions are present in the liver and there are no other sites of disease
- No pleural effusion or ascites requiring paracentesis within the past 4 weeks
- No known brain metastases
- ECOG performance status (PS) 0-1 OR Karnofsky PS 70-100%
- Life expectancy \> 3 months
- Absolute neutrophil count \>= 1,500/mm\^3
- Platelet count \>= 75,000/mm\^3
- Bilirubin =\< 2 times upper limit of normal (ULN)
- AST and ALT =\<2.5 times ULN (5 times ULN if liver involvement by tumor)
- Creatinine =\< 2 times ULN
- PT =\< 1.5 times ULN (no anticoagulation)
- Albumin \>= 2.5 mg/dL
- No history of allergic reactions attributed to compounds of similar chemical or biological composition to dasatinib
- No evidence of encephalopathy
- No condition that would preclude ability to swallow and retain dasatinib tablets, including any of the following:
- Gastrointestinal tract disease resulting in an inability to take oral medication;
- Requirement for IV alimentation;
- Prior surgical procedures affecting absorption:
- Active peptic ulcer disease
- No clinically significant ECG abnormalities
- No clinically significant cardiovascular disease, including any of the following:
- Myocardial infarction or ventricular tachyarrhythmia within the past 6 months;
- Prolonged QTc \>= 480 msec (Fridericia correction);
- Major conduction abnormality (unless cardiac pacemaker is present)
- No other uncontrolled illness, including, but not limited to, any of the following:
- Ongoing or active infection;
- History of significant bleeding disorder, including congenital (von Willebrand's disease) or acquired disorders (antifactor VIII antibodies);
- Psychiatric illness or social situation that would preclude study compliance
- Not pregnant or nursing
- Negative pregnancy test
- Fertile patients must use effective contraception
- Recovered from all prior therapy
- One prior systemic chemotherapy regimen allowed
- Prior cryosurgery allowed
- More than 4 weeks since prior transarterial chemoembolization
- More than 4 weeks since prior radiotherapy
- Prior or concurrent localized palliative radiotherapy (i.e., bony metastasis) allowed provided it was administered for =\< 3 days
- At least 7 days since prior and no concurrent antithrombotic and/or antiplatelet agents (e.g., warfarin, heparin, low molecular weight heparin, acetylsalicylic acid, and/or ibuprofen)
- At least 7 days since prior and no concurrent agents with proarrhythmic potential
- At least 7 days since prior and no concurrent medications or substances that are potent inhibitors or inducers of CYP3A4
- No concurrent combination antiretroviral therapy for HIV-positive patients
- No concurrent embolization or chemoembolization
- No concurrent systemic antacids (H2 receptor antagonists or proton pump inhibitors)
- Locally active antacids allowed provided they are held for 2 hours before and 2 hours after dasatinib dose
- No other concurrent investigational agents
- No other concurrent anticancer agents or therapies
Exclusion
Key Trial Info
Start Date :
April 1 2007
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
April 1 2011
Estimated Enrollment :
25 Patients enrolled
Trial Details
Trial ID
NCT00459108
Start Date
April 1 2007
End Date
April 1 2011
Last Update
April 19 2018
Active Locations (1)
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1
University of Southern California, Norris
Los Angeles, California, United States, 90033