Status:
COMPLETED
The Importance of Adrenomedullin (AM) on ACTH-Cortisol-Glucose Axis
Lead Sponsor:
University of Sao Paulo
Collaborating Sponsors:
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior.
Conditions:
Systemic Inflammatory Response Syndrome
Hyperglycemia
Eligibility:
All Genders
2-16 years
Brief Summary
Hyperglycemia is frequent manifestations of the human metabolic response to systemic inflammatory response syndrome (SIRS),sepsis and septic shock, and are implicated in the clinical outcome. Adrenom...
Detailed Description
Studies in cultured vascular endothelial cells and vascular smooth muscle cells demonstrate that cytokines strongly stimulate adrenomedullin production and release. Adrenomedullin has been measured i...
Eligibility Criteria
Inclusion
- Children above 2 years, submitted to elective cardiopulmonary bypass (CPB, only interatrial or ventricular communication) with no endocrine disease or infection.
Exclusion
- Children with endocrine disease, undernutrition, with some medication that might interfere in the study (corticosteroids.
Key Trial Info
Start Date :
January 1 2006
Trial Type :
OBSERVATIONAL
End Date :
October 1 2006
Estimated Enrollment :
20 Patients enrolled
Trial Details
Trial ID
NCT00459511
Start Date
January 1 2006
End Date
October 1 2006
Last Update
April 12 2007
Active Locations (1)
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1
Childrens Institute
São Paulo, São Paulo, Brazil, 05403000