Status:
TERMINATED
PET Evaluation of Brain Peripheral Benzodiazepine Receptors Using [11C]PBR28 in HIV-Seropositive Patients With (MCMD)
Lead Sponsor:
National Institute of Mental Health (NIMH)
Conditions:
HIV-Dementia
HIV-Associated Cognitive Motor Complex
Eligibility:
All Genders
18-50 years
Phase:
NA
Brief Summary
The purpose of this protocol is to measure a receptor in the brain using positron emission tomography (PET) that is involved in inflammation.
Detailed Description
The peripheral benzodiazepine receptor (PBR) is distinct from central benzodiazepine receptors associated with GABAa receptors. Although PBR was initially identified in peripheral organs such as kidne...
Eligibility Criteria
Inclusion
- INCLUSION CRITERIA:
- Inclusion criteria (healthy control subjects) aged 18 50 years with history/physical exam, ECG, and laboratory tests, plus inclusion criteria listed will be included in the protocol.
- HIV-seropositive based on ELISA and Western blot (except the HIV-seronegative subjects, who will have ELISA screening).
- Capable of providing informed consent.
- Ambulatory at initial visit.
- If cognitively impaired, the degree of impairment will be MCMD, and not frank HIV-associated dementia.
- EXCLUSION CRITERIA:
- Current psychiatric illness or severe systemic disease based on history and physical exam
- Current dependence on alcohol or substances other than nicotine.
- Laboratory results from blood or urine tests that show clinically significant abnormalities.
- Previous radiation exposure (X-rays, PET scans etc.) that would exceed research limits.
- Pregnancy and breast feeding.
- A history of brain disease.
- Cannot lie on your back for long periods since the pictures will be taken for about 2.5 hours during which time you will have to lie still on the scanner bed.
- More than moderate hypertension.
- Positive result on urine screen for illicit drugs.
Exclusion
Key Trial Info
Start Date :
April 9 2007
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
April 6 2014
Estimated Enrollment :
40 Patients enrolled
Trial Details
Trial ID
NCT00459693
Start Date
April 9 2007
End Date
April 6 2014
Last Update
September 10 2020
Active Locations (1)
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1
National Institutes of Health Clinical Center, 9000 Rockville Pike
Bethesda, Maryland, United States, 20892