Status:
COMPLETED
Effects of Antibodies to White Blood Cells on Platelet Transfusion Patients
Lead Sponsor:
National Institutes of Health Clinical Center (CC)
Conditions:
Healthy
Transfusion Reactions
Eligibility:
All Genders
18+ years
Brief Summary
This study will determine if transfusion of platelets containing HLA antibodies (certain antibodies to white blood cells) are more likely to cause transfusion reactions than transfusion of platelets t...
Detailed Description
Leukocyte antibodies can cause febrile transfusion reactions, pulmonary reactions to granulocyte transfusions, and transfusion related acute lung injury (TRALI). Despite the fact that the role of leuk...
Eligibility Criteria
Inclusion
- INCLUSION CRITERIA:
- Both male and female donors
- Any ethnic group
- 18 years of age or older
- Must meet the criteria for donating platelets in the DTM
- EXCLUSION CRITERIA:
- 1\. Donors are not eligible to donate platelets in the DTM
Exclusion
Key Trial Info
Start Date :
April 10 2007
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
August 10 2012
Estimated Enrollment :
135 Patients enrolled
Trial Details
Trial ID
NCT00460122
Start Date
April 10 2007
End Date
August 10 2012
Last Update
December 12 2019
Active Locations (1)
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1
National Institutes of Health Clinical Center, 9000 Rockville Pike
Bethesda, Maryland, United States, 20892