Status:
COMPLETED
Valsartan Optimal Therapy Against Elevated Home Blood Pressure Research（VOYAGER）Study
Lead Sponsor:
Kitakyushu-Tsuyazaki Hospital
Conditions:
Hypertension
Eligibility:
All Genders
20-80 years
Phase:
PHASE4
Brief Summary
The purpose of this study is to compare improvement percentage of urinary albumin excretion between valsartan 80 mg- and valsartan 160 mg-based therapy in patient with morning hypertension.
Detailed Description
The cardiovascular diseases such as stroke and myocardial infarction consist 50% of the cause of death in Japanese population. Numerous mega trials have shown that strict anti-hypertensive therapy cou...
Eligibility Criteria
Inclusion
- Outpatients aged over 20 years and less than 80 years, regardless of sex.
- Patients with stable seated morning home blood pressure of over 135 mmHg and/or diastolic blood pressure of over 85 mmHg within 1 to 2 weeks.
- Patients who are on therapy with conventional dosage of ARB.
Exclusion
- Patients who are difficult to measure home blood pressure.
- Patients with secondary hypertension or malignant hypertension.
- Patients with seated systolic blood pressure of over 200 mmHg.
- Patients with seated diastolic blood pressure of over 120 mmHg.
- Patients with a history of cerebrovascular disorder or myocardial infarction or heart failure within 6 months prior to enrolment in the study.
- Patients with atrial fibrillation, atrial flutter, or serious arrhythmia.
- Patients with renal dysfunction with serum creatinine level of over 2 mg/dL.
- Patients with serious liver dysfunction.
- Patient with HbA1C of over 8 percent.
- Patient with positive albuminuria by dip and read stick test.
- Patient treated with any angiotensin converting enzyme inhibitor
- Pregnant women
- Patients with a history of hypersensitivity to valsartan.
- Other patients who are judged to be inappropriate for the study by the investigator or sub-investigator.
Key Trial Info
Start Date :
July 1 2006
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
November 1 2013
Estimated Enrollment :
103 Patients enrolled
Trial Details
Trial ID
NCT00460213
Start Date
July 1 2006
End Date
November 1 2013
Last Update
December 9 2013
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
Koshiro Fukiyama
Kitakyushu, Fukuoka, Japan, 808-0024