Status:
COMPLETED
Glycoprotein and Glycan in Tissue and Blood Samples of Patients With Stage IB-IVA Cervical Cancer Undergoing Surgery to Remove Pelvic and Abdominal Lymph Nodes
Lead Sponsor:
Gynecologic Oncology Group
Collaborating Sponsors:
National Cancer Institute (NCI)
Conditions:
Cervical Adenocarcinoma
Cervical Adenosquamous Carcinoma
Eligibility:
FEMALE
18+ years
Brief Summary
This clinical trial studies glycoprotein and glycan in tissue and blood samples of patients with stage IB-IVA cervical cancer undergoing surgery to remove pelvic and abdominal lymph nodes. Studying sa...
Detailed Description
PRIMARY OBJECTIVE: I. Determine whether the presence of a mutation in T-synthase or Cosmc and/or the presence of positive immunohistochemical expression of Tn antigen or sialyl Tn antigen in tumor sp...
Eligibility Criteria
Inclusion
- Patients with primary, previously untreated, histologically confirmed locoregionally advanced (Stages IB2, IIA \> 4 cm, IIB-IVA) invasive carcinoma of the cervix (any cell type) who will undergo pelvic and para-aortic (abdominal) lymphadenectomy to determine the presence or absence of lymph node metastasis
- Patients who have met the pre-entry requirements
- Patients with a block or 25 unstained sections of formalin-fixed and paraffin-embedded primary tumor available to satisfy the primary tumor requirement
- Patients who have signed an approved informed consent and authorization permitting release of personal health information
Exclusion
- Patients who do not satisfy pre-entry requirements
Key Trial Info
Start Date :
April 2 2007
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
July 16 2016
Estimated Enrollment :
159 Patients enrolled
Trial Details
Trial ID
NCT00460356
Start Date
April 2 2007
End Date
July 16 2016
Last Update
August 24 2017
Active Locations (18)
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1
UC Irvine Health/Chao Family Comprehensive Cancer Center
Orange, California, United States, 92868
2
Olive View-University of California Los Angeles Medical Center
Sylmar, California, United States, 91342
3
Augusta University Medical Center
Augusta, Georgia, United States, 30912
4
Wayne State University/Karmanos Cancer Institute
Detroit, Michigan, United States, 48201