Status:
COMPLETED
Influence of Persistent CMV-infection on Immune Senescence
Lead Sponsor:
University of Zurich
Collaborating Sponsors:
Division of Infectious Diseases and Hospital Epidemiology
Conditions:
Immune Senescence
Eligibility:
All Genders
70+ years
Phase:
PHASE4
Brief Summary
Recent studies indicate that persistent viral infections particularly with Cytomegalovirus (CMV) might have a negative impact on immune senescence (i.e. immunocompetence of elderly individuals). We wi...
Eligibility Criteria
Inclusion
- Inclusion criteria:
- Age \> 70 years
- Healthy according to a health questionnaire (completed before screening)
- TBE-Vaccination indicated (exposure to TBEV-infested ticks possible)
- Capable to make an informed decision and to understand the informed consent form
- Informed consent signed by patient and study physician
- Exclusion criteria:
- Previous exposure to TBEV (natural or vaccination)
- Immunodeficiency, history of autoimmune disease or current intake of immune-modulating drugs (corticosteroids a.s.o.)
- Persistent (\> 3 months) pharmacological treatment with more than one drug of relevance (exception: combination antihypertensives)
- Contraindication for TBEV-vaccination
- Condition that would drastically interfere with clinic attendance and/or adherence to the protocol
- Past medical history or current treatment for one of the following conditions: Chronic cardiac disease (Coronary heart disease, heart failure), chronic pulmonary disease (COPD), chronic kidney disease, diabetes mellitus, previous stroke, epilepsy, Parkinsons disease, dementia
- Hemoglobin \<12 g/l
- Random plasma glucose (RPG) \> 11.1 mmol/l OR fasting plasma glucose (FPG) \> 6.9 mmol/l (FPG required, if RPG is 7.0-11.0 mmol/l)
- Calculated Creatinin-Clearance \< 50 ml/min
- TBEV-serology positive
Exclusion
Key Trial Info
Start Date :
May 1 2007
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 1 2010
Estimated Enrollment :
183 Patients enrolled
Trial Details
Trial ID
NCT00461695
Start Date
May 1 2007
End Date
December 1 2010
Last Update
August 27 2013
Active Locations (1)
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1
University Hospital Zurich, Department of Infectious Diseases and Hospital Epidemiology
Zurich, Switzerland