Status:
COMPLETED
Brain GABA Levels and Treatment Response in Major Depressive Disorder
Lead Sponsor:
Massachusetts General Hospital
Collaborating Sponsors:
Mclean Hospital
Conditions:
Major Depressive Disorder
Eligibility:
All Genders
18-65 years
Phase:
PHASE4
Brief Summary
This study will evaluate changes in brain gamma-aminobutyric acid (GABA) levels due to treatment with escitalopram in people with major depressive disorder.
Detailed Description
Major depressive disorder (MDD) is a severe form of depression. MDD can significantly interfere with an individual's thoughts, behavior, mood, and physical health. People who suffer from MDD often exp...
Eligibility Criteria
Inclusion
- Meet diagnostic criteria for current Major Depressive Disorder
- Men or women aged 18-65
- Medication-free for one week prior to the start of the study
- Agrees to use an effective form of contraception throughout the study
Exclusion
- Anyone who is suicidal
- Pregnant or breastfeeding women
- Anyone with a serious or unstable medical illness, including cardiovascular, hepatic, renal, respiratory, endocrine, neurologic or hematologic disease
- Anyone with a history of seizure disorder or hypothyroidism
- Anyone with a history of psychiatric disorders including bipolar disorder, schizophrenia, psychoses, or substance abuse (including alcohol abuse active within the last 12 months)
- Anyone with a history of intolerance or multiple adverse drug reactions or allergy to (es)citalopram.
- Patients who are currently taking medications active on GABA, including benzodiazepines.
Key Trial Info
Start Date :
September 1 2006
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
September 1 2009
Estimated Enrollment :
40 Patients enrolled
Trial Details
Trial ID
NCT00464711
Start Date
September 1 2006
End Date
September 1 2009
Last Update
January 4 2017
Active Locations (1)
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1
Depression Clinical and Research Program, Massachusetts General Hospital
Boston, Massachusetts, United States, 02114