Status:
COMPLETED
Transcranial Doppler (TCD) Assessment During Early Anti-thrombotic Therapy After Bioprosthetic Aortic Valve Replacement
Lead Sponsor:
Ottawa Heart Institute Research Corporation
Collaborating Sponsors:
Edwards Lifesciences
Conditions:
Aortic Valve Disease
Eligibility:
All Genders
18+ years
Brief Summary
The purpose of this study is to determine if there is any difference in the counts of cerebral emboli and platelet function between two prophylactic treatments of thrombosis currently used at Universi...
Detailed Description
Background: There are several medications used to prevent blood clotting in patients undergoing surgical replacement of their aortic valves with tissue valves. One of these medications is called warf...
Eligibility Criteria
Inclusion
- Patients undergoing primary aortic valve replacement with bioprosthetic (tissue) valve.
Exclusion
- Emergency surgery or redo operations.
- Patients with history of transient ischemic attacks, stroke, or history of carotid stenosis greater than 50% as detected by carotid duplex doppler or angiography.
- Patients with COPD who are CO2 retainers.
- Patients with LV function less than 50%, or enlarged left ventricle greater than 50 mm as detected by echocardiography or previous history of thromboembolism.
- Patients with history of atrial fibrillation or heart rhythm disturbances.
Key Trial Info
Start Date :
March 1 2007
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
March 1 2011
Estimated Enrollment :
56 Patients enrolled
Trial Details
Trial ID
NCT00465218
Start Date
March 1 2007
End Date
March 1 2011
Last Update
June 21 2012
Active Locations (1)
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1
University of Ottawa Heart Institute
Ottawa, Ontario, Canada, K1Y 4W7