Status:
COMPLETED
Effect of Fluvastatin on Top of Clopidogrel and Aspirin in Patients After DES Implantation on Platelet Aggregation
Lead Sponsor:
Insel Gruppe AG, University Hospital Bern
Conditions:
Drug-Interactions
Eligibility:
All Genders
18-95 years
Brief Summary
The purpose of the study was to determine the influence of fluvastatin and atorvastatin on platelet aggregation in patients treated with aspirin and plavix after coronary stenting. We hypothezied a po...
Detailed Description
1. Introduction Coronary stent implantation is performed in more than 80 % of all coronary interventions. The use of stents has significantly reduced re-stenosis rate in revascularization in compariso...
Eligibility Criteria
Inclusion
- all patients with stent implantation followed by treatment with aspirin and clopidogrel
- routinely treated with acetylsalicylic 100 mg/day
Exclusion
- acute coronary syndrome
- use of a GPIIb/IIIa inhibitor
- allergy to acetylsalicylic acid, clopidogrel, statins
- elevated liver enzymes (\> 3 x norm value)
- muscle myopathy
- active liver disease
- recent gastrointestinal bleeding (\< 3 months)
- known platelet dysfunction or abnormal platelet count
- pregnancy
- indication for treatment with non-steroidal drugs
- indication for long-term treatment with a drug metabolized by cytochrome p450 3A4 or 2C9
Key Trial Info
Start Date :
Trial Type :
OBSERVATIONAL
End Date :
Estimated Enrollment :
100 Patients enrolled
Trial Details
Trial ID
NCT00465322
Last Update
April 25 2007
Active Locations (1)
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1
Cardiology University Hospital
Bern, Switzerland, 3010