Status:
WITHDRAWN
The Antioxidant Effect of Routine Vascular Therapy for Normal Tension Glaucoma Patients
Lead Sponsor:
University Hospital, Basel, Switzerland
Conditions:
Primary Open Angle Glaucoma
Eligibility:
All Genders
18-65 years
Brief Summary
To quantify oxidative stress in circulating leukocytes of normal tension glaucoma patients, prior to and one month after routine vascular therapy.
Detailed Description
There are two accepted medical modalities for glaucoma treatment. The first, is a local application of an intraocular pressure (IOP) lowering drug. The second, is the application of systemic drugs to ...
Eligibility Criteria
Inclusion
- For NTG patients:
- A mean untreated intraocular pressure consistently equal to or below 21mmHg or median intraocular pressure equal to or below 20mmHg on diurnal testing (at least three measurements) with no single measurement greater than 24mmHg
- Open drainage angles on gonioscopy
- Typical optic disc damage with glaucomatous cupping and thinning of neuroretinal rim
- Visual field defect congruent to glaucomatous disc alteration
- No other pathological findings upon slit-lamp examination and indirect fundoscopy
- Vasospastic propensity will be assumed if a clear history of frequent cold hands (answering yes to the questions:" Do you always have cold hands, even during the summer time?" and "Do other people tell you that you have cold hands?") is reported.
- For healthy subjects:
- An intraocular pressure \< 20 mmHg
- No history of ocular or systemic disease
- No history of chronic or current systemic or topical medication, or of drug or alcohol abuse
- Normal blood pressure (100-140/60-90mm Hg)
- Best corrected visual acuity above 20/32 in both eyes
- No pathological findings upon slit-lamp examination and indirect fundoscopy
Exclusion
- EXCLUSION CRITERIA:
- Iridocorneal angle extremely narrow with complete or partial closure as determined by gonioscopy
- Pigmentary dispersion or pseudoexfoliation
- Evidence for any secondary cause for a glaucomatous optic neuropathy (trauma, steroids, uveitis)
- History of chronic or recurrent severe inflammatory eye disease (eg. scleritis, uveitis) or clinically significant or progressive retinal disease (eg. diabetic retinopathy)
- History of ocular trauma or intraocular surgery within the past 6 months
- History of systemic infection or inflammation within the past 3 months
- Need for any concomitant medications that may interfere with the evaluation of leukocytes (eg: steroids, immunosuppressives)
- Patients with a significant history and /or active alcohol or drug abuse (significant is defined as that which may influence results of the study)
Key Trial Info
Start Date :
June 1 2009
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
June 1 2010
Estimated Enrollment :
Patients enrolled
Trial Details
Trial ID
NCT00465348
Start Date
June 1 2009
End Date
June 1 2010
Last Update
October 25 2012
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