Status:
COMPLETED
Impact of Switching to Continuous Release Dopamine Agonists
Lead Sponsor:
University of Toledo
Conditions:
Parkinson Disease
Eligibility:
All Genders
55+ years
Phase:
PHASE3
Brief Summary
The purpose of this proposal is to determine if switching PD patients treated with pramipexole to ropinirole CR reduces the non-motor side effects frequently experienced by these patients. Side effect...
Detailed Description
The purpose of this proposal is to determine if switching PD patients treated with pramipexole to ropinirole CR reduces the non-motor side effects frequently experienced by these patients. Side effect...
Eligibility Criteria
Inclusion
- Each subject must meet all of the following inclusion criteria to qualify for entrance into the study:
- Subjects who are male or female and are aged 55 and older.
- Subjects and/or their legal guardians must be able and willing to give informed consent.
- Subjects must be on stable doses of pramipexole for greater than 4 weeks duration prior to screening.
- Subjects who are female must be non-pregnant and non-nursing. Women of Child-Bearing Potential (WOCBP) must use a reliable method of contraception (e.g., oral contraceptive or long-term injectable or implantable hormonal contraceptive, double-barrier methods, such as condom and diaphragm, condom and foam, condom and sponge or intra-uterine devices) and have a negative serum pregnancy test at screening. Women are considered to not be of child-bearing potential if they have been surgically sterilized (physician-documented hysterectomy or tubal ligation) or if they are post-menopausal.
- Subjects must have a clinical diagnosis of Parkinson's based on the presence of at least 2 of the 3 cardinal criteria - rest tremor, bradykinesia, rigidity - and no obvious history of head trauma, stroke, infectious, structural, or metabolic abnormality consistent with an alternative diagnosis to Parkinson's disease.
- Evidence of one or more of the following symptoms: somnolence (ESS score ≥ 9), cognitive decline (MMSE \< 24 ± presence of hallucinations (NPI-Q), peripheral edema (present by objective physical exam with baseline ankle and calf circumference measured in centimeters).
Exclusion
- A subject who meets any of the following criteria will NOT qualify for the study:
- Subjects must not be receiving any treatments for excess somnolence such as amphetamine derivatives, other stimulants or Provigil.
- Subjects with actively treated malignancies, clinically significant heart disease, kidney, liver, or pulmonary disorders will be excluded.
- Subjects with clinical depression who are not receiving stable doses of antidepressant therapy in excess of 4 weeks duration.
- Subjects with history of orthostatic hypotension (\>30mm drop in systolic pressure and/or \>20mm drop in diastolic pressure) associated with syncope.
- Subjects started within the last 14 days on any drug known to substantially inhibit CYP1A2 (e.g., cimetidine, fluvoxamine) or induce CYP1A2 (e.g.omeprazole) (Note: Subjects already on these agents may be enrolled but must remain on the stable doses of the agents from 14 days prior to the beginning of the study).
- Subjects who have other medical conditions that are considered clinically unstable or that may compromise the safety of the patient during this study.
Key Trial Info
Start Date :
January 1 2007
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 1 2011
Estimated Enrollment :
11 Patients enrolled
Trial Details
Trial ID
NCT00465452
Start Date
January 1 2007
End Date
December 1 2011
Last Update
May 16 2025
Active Locations (1)
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1
Medical University of Ohio
Toledo, Ohio, United States, 43614