Status:
COMPLETED
MR, Myocardial Infarct and Heart Failure
Lead Sponsor:
Helse Stavanger HF
Collaborating Sponsors:
Helse Vest
Norwegian Foundation for Health and Rehabilitation
Conditions:
Heart Failure, Congestive
Eligibility:
All Genders
18+ years
Brief Summary
KoMPiS is a contrast aided cardiac magnetic resonance study of microvascular obstruction and left ventricular remodelling following acute revascularised anterior myocardial infarction. The study will ...
Detailed Description
Introduction. Cardiovascular disease is responsible for 30 % of worldwide mortality, accounting for approximately 15 million deaths per year. Improvement in medical treatment strategies during the las...
Eligibility Criteria
Inclusion
- Men or women \> 18 years of age, non-child bearing potential
- First time acute myocardial infarction, as determined by evidence of transmural ischemia in the ECG and a rise in cardiac-Troponin-T (TNT) \> 0,1 (μg/l), followed by
- A successful acute PCI of a single vessel disease with a proximal/mid left anterior descent artery (LAD), circumflex artery (RCX) or right coronary artery (RCA) lesion (the index PCI).
Exclusion
- Extensive cardiopulmonary resuscitation.
- Haemodynamically unstable patients, unable to leave the coronary care unit for the CMR examination.
- Use of fibrinolytics immediately prior to the index PCI.
- Significant primary valve disease,
- Autoimmune disease causing an increase in collagen turnover
- Active cancer disease
- Need for immunosuppressive treatment,
- Significantly reduced liver function
- Contraindications for performing a cardiac MRI-scan (claustrophobia, and implanted ferromagnetic devices, known allergic reactions to Omniscan™).
- Inability to understand the consent form or cooperate during the 1 year follow up.
- Comorbidity with poor prognosis.
Key Trial Info
Start Date :
December 1 2004
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
May 1 2007
Estimated Enrollment :
44 Patients enrolled
Trial Details
Trial ID
NCT00465868
Start Date
December 1 2004
End Date
May 1 2007
Last Update
July 28 2015
Active Locations (1)
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1
Stavanger University Hospital
Stavanger, Norway, NO-4011