Status:
COMPLETED
The Effect of Serum LDL Lowering on Aspirin Resistance
Lead Sponsor:
Ziv Hospital
Conditions:
Aspirin Resistance
Hypercholesterolemia
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
Aspirin resistance is the persistent platelet activation, demonstrated by platelet function tests (1). The hypothesis is that:LDL lowering by statin in patients with aspirin resistance can improve th...
Detailed Description
The patients will be treated by aspirin loading dose of 500mg and then 100 mg/day for other 4 days. For patients that will be entrolled in the regular working hours, platelet aggregation test and chol...
Eligibility Criteria
Inclusion
- Hypercholesterolemic low-moderate risk patients without hypolipidemic drugs for at least one month.
- Age ≥18 years on stable AHA step 1 diet.
- For primary prevention, LDL \> 130 mg/dL and for secondary prevention LDL\>70 and \<100mg/dL. .
- CPK, ALT and AST \< 1.5 x upper limit of normal at baseline.
Exclusion
- Women currently receiving cyclical hormones.
- Treatment with hypolipidemic drugs during the last month.
- Oral corticosteroids, NSAID, COX-1 inhibitors and other antiplatelet drugs.
- Women with childbearing potential unless on safe contraception.
- Psychiatric disease with defect in judgement.
- Severe renal or hepatic diease.
- Uncontrolled hypo- or hyperthyroidism.
- Contraindication for ezetimibe or statin treatment.
Key Trial Info
Start Date :
July 1 2005
Trial Type :
INTERVENTIONAL
End Date :
January 1 2007
Estimated Enrollment :
40 Patients enrolled
Trial Details
Trial ID
NCT00466154
Start Date
July 1 2005
End Date
January 1 2007
Last Update
February 20 2013
Active Locations (1)
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1
Internal Medicine Department A ,Ziv Goverment Hospital
Safed, Israel, 13110