Status:
COMPLETED
Noninvasive Methods to Monitor Graft Survival in Heart Transplant Patients
Lead Sponsor:
National Institute of Allergy and Infectious Diseases (NIAID)
Collaborating Sponsors:
National Heart, Lung, and Blood Institute (NHLBI)
Clinical Trials in Organ Transplantation
Conditions:
Heart Transplant
Eligibility:
All Genders
10+ years
Brief Summary
Injury of transplant tissue by a transplant recipient's immune system continues to be the leading cause of graft rejection and recipient death. The purpose of this study is to identify a single test o...
Detailed Description
A major cause of heart transplant failure is the blockage of blood flow from lesions caused by ongoing injury and repair of the graft by the host's immune system. However, the role of T cells, antibod...
Eligibility Criteria
Inclusion
- Age greater than 10 and a body mass of 30 kg (66 lbs) or more
- On waiting list for a heart transplant for whom a donor heart available
- Willing to comply with study protocol
- Willing to use acceptable forms of contraception
- Parent or guardian willing to provide consent, if applicable
Exclusion
- Receiving multiple organ transplants
- Previously received organ transplants
- Other comorbidities that, in the opinion of the site investigator, would interfere with the study
- Currently taking immunosuppression for nontransplant reasons
- Participation in an interventional clinical trial
- Pregnancy or breastfeeding
Key Trial Info
Start Date :
June 1 2007
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
July 1 2011
Estimated Enrollment :
263 Patients enrolled
Trial Details
Trial ID
NCT00466804
Start Date
June 1 2007
End Date
July 1 2011
Last Update
January 1 2016
Active Locations (12)
Enter a location and click search to find clinical trials sorted by distance.
1
University of California
San Francisco, California, United States, 94143
2
Northwestern University Medical School
Chicago, Illinois, United States, 60611
3
Loyola University School of Medicine
Maywood, Illinois, United States, 60153
4
University of Maryland
Baltimore, Maryland, United States, 21201