Status:
TERMINATED
Characteristics of Parkinson s Disease Associated With the LRRK-2 Gene Mutation
Lead Sponsor:
National Institute of Neurological Disorders and Stroke (NINDS)
Conditions:
Parkinson Disease
Eligibility:
All Genders
18+ years
Brief Summary
This study will identify symptoms and other characteristics of Parkinson s disease that may be associated with changes in a gene called leucine-rich repeat kinase 2 (LRRK2). Changes in this gene have ...
Detailed Description
Parkinson s disease is a common neurological condition that was originally thought to develop from environmental factors. More recently, genetic factors have been implicated. In this study, we are int...
Eligibility Criteria
Inclusion
- INCLUSION CRITERIA:
- Subjects at least 18 years of age.
- Ability to provide consent or have appointed a Durable Power of Attorney able to provide consent.
- Patients with a diagnosis of PD with a known LRRK2 mutation.
- OR
- First degree relatives without a diagnosis of PD with a family history suggestive of inherited PD due to LRRK2 mutations.
- EXCLUSION CRITERIA:
- Subjects with a history of severe head injury, encephalitis, chronic use of drugs that cause parkinsonism or a clinical history of strokes.
- For the magnetic resonance imaging (MRI), exclusion criteria include the following: pregnancy, pacemakers or other implanted electrical devices, brain stimulators, dental implants, aneurysm clips (metal clips on the wall of a large artery), metallic prostheses (including metal pins and rods, heart valves, and cochlear implants), permanent eyeliner, implanted delivery pump, or shrapnel fragments. Patients will be screened for these conditions prior to having the MRI scan performed.
Exclusion
Key Trial Info
Start Date :
April 23 2007
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
February 3 2014
Estimated Enrollment :
34 Patients enrolled
Trial Details
Trial ID
NCT00467090
Start Date
April 23 2007
End Date
February 3 2014
Last Update
December 17 2019
Active Locations (1)
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1
National Institutes of Health Clinical Center, 9000 Rockville Pike
Bethesda, Maryland, United States, 20892