Status:
COMPLETED
Effect of Daily Calorie or Alternate-day Calorie Reductions on Risk for Cardiovascular Disease and Cancer
Lead Sponsor:
University of California, San Francisco
Collaborating Sponsors:
National Institutes of Health (NIH)
Conditions:
Moderately Overweight Individuals
Eligibility:
All Genders
35-65 years
Phase:
NA
Brief Summary
The purpose of this study is to examine and compare the effects of alternate-day reductions in calorie intake or daily calorie restriction on the risk for cardiovascular disease and cancer.
Detailed Description
Overweight individuals are at greater risk for certain chronic diseases such as cardiovascular disease and cancer when compared to those who are normal weight. Dietary restriction has been shown to lo...
Eligibility Criteria
Inclusion
- Male and female; body mass index (BMI) between 20-30 kg/m2;
- Age between 35-65 years; sedentary (light exercise less than 1h per week) or moderately active (1 to 2h per week);
- Weight stable for \>3 months prior to the beginning of the study;
- Able to give written informed consent;
- Female subjects must be post-menopausal for at least 2 years and can not be on hormone replacement therapy (HRT).
Exclusion
- Diabetic;
- History of cardiovascular disease, i.e. myocardial infarction or stroke;
- History of cancer;
- Taking glucose lowering medication;
- Taking weight loss medication
Key Trial Info
Start Date :
April 1 2007
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 17 2015
Estimated Enrollment :
24 Patients enrolled
Trial Details
Trial ID
NCT00467220
Start Date
April 1 2007
End Date
December 17 2015
Last Update
January 22 2020
Active Locations (1)
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1
San Francisco General Hospital
San Francisco, California, United States, 94110