Status:
TERMINATED
Vaccine Therapy With or Without Donor Lymphocyte Infusion in Treating Patients With Acute Myeloid Leukemia, Acute Lymphoblastic Leukemia, or Multiple Myeloma Undergoing Donor Stem Cell Transplant
Lead Sponsor:
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
Collaborating Sponsors:
National Cancer Institute (NCI)
Conditions:
Leukemia
Multiple Myeloma and Plasma Cell Neoplasm
Eligibility:
All Genders
18-70 years
Phase:
PHASE1
Brief Summary
RATIONALE: Vaccines made from the patient's cancer cells may help the body build an effective immune response to kill cancer cells. Giving vaccine therapy together with donor lymphocyte infusion after...
Detailed Description
OBJECTIVES: * Determine time to relapse and overall survival of patients with high-risk acute myeloid leukemia, acute lymphoblastic leukemia, or multiple myeloma treated with autologous tumor cell va...
Eligibility Criteria
Inclusion
- DISEASE CHARACTERISTICS:
- Confirmed diagnosis of 1 of the following:
- Acute myeloid leukemia (AML), meeting any of the following criteria:
- Relapsed disease
- AML arising from myelodysplastic syndromes
- Primary refractory disease
- De novo AML with high-risk features
- Acute lymphoblastic leukemia (ALL), meeting any of the following criteria:
- De novo ALL that is Philadelphia chromosome positive or with t(4,11) cytogenetic features
- Relapsed disease
- Multiple myeloma (in need of treatment)
- Planning to undergo HLA-matched related sibling nonmyeloablative hematopoietic stem cell transplantation
- PATIENT CHARACTERISTICS:
- Not specified
- PRIOR CONCURRENT THERAPY:
- See Disease Characteristics
Exclusion
Key Trial Info
Start Date :
April 1 2007
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
March 1 2010
Estimated Enrollment :
1 Patients enrolled
Trial Details
Trial ID
NCT00469820
Start Date
April 1 2007
End Date
March 1 2010
Last Update
March 21 2014
Active Locations (1)
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1
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
Baltimore, Maryland, United States, 21231-2410