Status:
WITHDRAWN
Enzastaurin, Carboplatin, and Gemcitabine With or Without Bevacizumab in Treating Patients With Recurrent, Stage IIIB, or Stage IV Non-Small Cell Lung Cancer
Lead Sponsor:
Eastern Cooperative Oncology Group
Collaborating Sponsors:
National Cancer Institute (NCI)
Conditions:
Lung Cancer
Eligibility:
All Genders
18-120 years
Phase:
PHASE2
Brief Summary
RATIONALE: Enzastaurin may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth and by blocking blood flow to the tumor. Drugs used in chemotherapy, such as carboplati...
Detailed Description
OBJECTIVES: Primary * Determine the progression-free survival in patients with recurrent or stage IIIB or IV non-small cell lung cancer treated with carboplatin, gemcitabine, and enzastaurin with or...
Eligibility Criteria
Inclusion
- DISEASE CHARACTERISTICS:
- Histologically or cytologically confirmed non-small cell lung cancer (NSCLC)
- Stage IIIB (with confirmed malignant pleural effusion), stage IV, or recurrent disease
- Mixed tumors categorized by the predominant cell type are allowed provided no small cell elements exist
- Cytologic or histologic elements can be established on metastatic tumor aspirates or biopsy
- Measurable disease as defined by RECIST criteria
- No squamous cell carcinoma (group 1)
- No history of brain metastases (group 1)
- History of treated brain metastases allowed provided patient is not taking steroids and anti-seizure mediation (group 2)
- PATIENT CHARACTERISTICS:
- ECOG performance status 0-1
- ANC ≥ 1,500/mm³
- Platelet count ≥ 100,000/mm³
- Bilirubin ≤ 1.5 mg/dL
- Creatinine ≤ 1.5 times upper limit of normal (ULN)
- Alkaline phosphatase ≤ 3 times ULN (≤ 5 times ULN with liver metastases)
- AST and ALT ≤ 3 times ULN (≤ 5 times ULN with liver metastases)
- INR \< 1.5 or PTT normal (group 1)
- Not pregnant or nursing
- Negative pregnancy test
- Fertile patients must use effective contraception during (groups 1 and 2) and for 6 months after completion of study treatment (group 1)
- No preexisting peripheral neuropathy ≥ grade 2
- Must be able to swallow tablets
- No cardiovascular condition, including any of the following:
- Myocardial infarction within the past 6 months
- Cerebrovascular ischemia or stroke within the past 6 months
- NYHA congestive heart failure \> class II
- Unstable angina pectoris
- Serious cardiac arrhythmia requiring medication
- Significant vascular disease
- Symptomatic peripheral vascular disease
- No concurrent medical condition, psychiatric illness, or limitations that would limit study compliance
- No ongoing active infection or ongoing fever within the past 6 months
- No history of uncontrolled hypertension, defined as blood pressure ≥ 150/90 mm Hg despite being on a stable regimen of anti-hypertensive therapy
- No serious nonhealing wound, ulcer, or bone fracture within the past 4 weeks
- No ongoing or active infection
- No history of thrombotic or hemorrhagic disorders, bleeding diathesis, or coagulopathy (group 1)
- No bleeding \> grade 2 or any bleeding requiring intervention within the past 4 weeks (group 1)
- No history of gross hemoptysis (defined as \> ½ teaspoon of bright red blood) (group 1)
- Urine protein:creatinine (UPC) ratio \< 1.0 by spot urinalysis
- For UPC ratio \> 0.5, a 24-hour urine protein must be obtained and the urine protein level must be \< 1,000 mg (group 1)
- None of the following conditions (group 1):
- Grade II or greater peripheral vascular disease
- Abdominal fistula
- Gastrointestinal perforation
- Intra-abdominal abscess
- No known hypersensitivity to any component of bevacizumab (group 1)
- No history of hypertensive crisis or hypertensive encephalopathy (group 1)
- PRIOR CONCURRENT THERAPY:
- More than 4 weeks since prior major surgical procedure
- More than 7 days since prior minor surgical procedure
- No prior chemotherapy for advanced NSCLC
- Postoperative adjuvant chemotherapy for previously resected NSCLC allowed if last dose was given \> 1 year ago
- More than 3 weeks since prior radiation therapy and recovered
- More than 3 weeks since prior immunotherapy and/or hormonal therapy (not including hormone replacement therapy or contraceptives) and recovered
- More than 14 days since prior enzyme inducing anti-epileptic drugs (EIAEDs)
- More than 10 days since prior and no concurrent daily treatment with acetylsalicylic acid (\> 325 mg/day) or NSAIDs known to inhibit platelet function for chronic conditions (group 1)
- No concurrent major surgical procedure (group 1)
- No concurrent carbamazepine, phenobarbital, or phenytoin
- No concurrent therapeutic anticoagulation (group 1)
- Prophylactic anticoagulation of venous access devices is allowed
- No concurrent treatment with dipyridamole, ticlopidine, clopidogrel, or cilostazol (group 1)
- No concurrent combination antiretroviral therapy for HIV-positive patients
Exclusion
Key Trial Info
Start Date :
June 1 2007
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
Estimated Enrollment :
Patients enrolled
Trial Details
Trial ID
NCT00469976
Start Date
June 1 2007
Last Update
October 8 2015
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