Status:
COMPLETED
Randomised Placebo Controlled Study of Effects of Therapeutic Hookworm Infection in Asthma
Lead Sponsor:
University of Nottingham
Conditions:
Asthma
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
There has been considerable debate over the last 30 years about the interaction between asthma and parasitic infection. It has been suggested that at least part of the reason for the increasing preval...
Detailed Description
Epidemiological evidence suggests that human hookworm infection is associated with a reduced risk of asthma and allergic disease. This association is potentially important not only to understanding th...
Eligibility Criteria
Inclusion
- Clinical diagnosis of asthma
- Use of regular inhaled corticosteroid treatment to a maximum of 1000mcg beclomethasone or equivalent per day
- Measurable airway responsiveness to AMP
- Negative hookworm serology
- Positive skin prick tests to D.pteronyssinum, cat fur or grass pollen
Exclusion
- Possible or planned pregnancy or breastfeeding
- Use of regular oral corticosteroids or immunosuppressive medication
- Anemia
- History of anaphylaxis
Key Trial Info
Start Date :
January 1 2007
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
October 1 2007
Estimated Enrollment :
30 Patients enrolled
Trial Details
Trial ID
NCT00469989
Start Date
January 1 2007
End Date
October 1 2007
Last Update
January 11 2008
Active Locations (1)
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1
University of Nottingham
Nottingham, United Kingdom, NG5 1PB