Status:
COMPLETED
Effects of PPAR Ligands on Ectopic Fat Accumulation and Inflammation
Lead Sponsor:
VA Office of Research and Development
Conditions:
Metabolic Syndrome X
Prediabetic State
Eligibility:
All Genders
18-65 years
Phase:
NA
Brief Summary
The relationship between obesity and insulin resistance is known, however the mechanism(s) associating obesity with insulin resistance is not well understood. Inflammation and accumulation of fat in n...
Detailed Description
The correlation between obesity, inflammation and ectopic fat accumulation is well recognized; however, the mechanism(s) responsible for obesity induced insulin resistance is not well understood. The ...
Eligibility Criteria
Inclusion
- Impaired glucose tolerance and/or impaired fasting glucose and/or metabolic syndrome
- Age 18-65
- BMI 28-38
Exclusion
- Renal insufficiency: creatinine.1.4
- Liver disease: ALT.2x normal, congestive heart failure, history of documented coronary artery disease, concomitant use HMG CoA-reductase inhibitors (statins)
- Concurrent use of ASA, steroids and other anti-inflammatory agents
Key Trial Info
Start Date :
January 1 2007
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
June 1 2014
Estimated Enrollment :
27 Patients enrolled
Trial Details
Trial ID
NCT00470262
Start Date
January 1 2007
End Date
June 1 2014
Last Update
July 21 2016
Active Locations (1)
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1
VA Eastern Colorado Health Care System, Denver
Denver, Colorado, United States, 80220