Status:
WITHDRAWN
Transcranial Magnetic Stimulation for Bipolar Depression
Lead Sponsor:
The University of New South Wales
Conditions:
Bipolar Depression
Eligibility:
All Genders
18-80 years
Phase:
PHASE1
PHASE2
Brief Summary
This is a study to assess the effectiveness of repetitive transcranial magnetic stimulation (rTMS) as a treatment for depressed adults with bipolar disorder. In rTMS high-intensity, fluctuating magne...
Detailed Description
Inpatients and outpatients with major depressive episodes as part of either bipolar I or II illness will be eligible. In the event that patients (in any arm) have no significant response after a defin...
Eligibility Criteria
Inclusion
- DSM-IV Major Depressive Episode of no more than 3 years.
- Diagnosis of bipolar I or II disorder
- Montgomery-Asberg Depression Rating Scale score of 20 or more.
- Aged over 18
- May or may not be taking antidepressant medication.
Exclusion
- Patient not able to give informed consent.
- Failure to respond to ECT in current episode of depression.
- Significant other Axis I psychiatric disorders e.g. schizophrenia.
- In imminent physical or psychological danger, or needs rapid clinical response due to inanition, psychosis or high suicide risk.
- Comorbid substance abuse or dependence
- History of neurological illness e.g. epilepsy; neurosurgical procedure
- Metal in the cranium, a pacemaker, cochlear implant, medication pump or other electronic device.
- Women of child-bearing age in whom pregnancy cannot be ruled out.
- Patients with a history of mood 'switching' in response to other treatments.
Key Trial Info
Start Date :
April 1 2007
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 1 2008
Estimated Enrollment :
Patients enrolled
Trial Details
Trial ID
NCT00470639
Start Date
April 1 2007
End Date
December 1 2008
Last Update
April 3 2023
Active Locations (2)
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1
Black Dog Research Institute
Sydney, New South Wales, Australia
2
Northside Clinic
Sydney, New South Wales, Australia