Status:
UNKNOWN
Compare Efficacy of Gastric Acid Suppression by Oral and Intravenous Administration of Esomeprazole in Patients With Peptic Ulcer
Lead Sponsor:
Pamela Youde Nethersole Eastern Hospital
Conditions:
Peptic Ulcer
Eligibility:
All Genders
18-90 years
Phase:
PHASE4
Brief Summary
The purpose of this study is to compare the gastric acid suppression profile among different regimen (Oral Vs Intravenous)of administration of proton pump inhibitor - Esomeprazole by 24hours intragast...
Detailed Description
Peptic ulcer bleeding is a common medical emergency. Although primary hemostasis can be achieved by endoscopic hemostasis in more than 90% of cases, rebleeding during the first 72 hours is still commo...
Eligibility Criteria
Inclusion
- Patients with non-bleeding peptic ulcer which do not require endoscopic therapy.
- Chinese, Age ³18 and \<90
- Provision of an informed written consent signed by the patient.
Exclusion
- Treatment of antisecretory drugs during the preceding 4 weeks
- The present inter-current ulcer complication (gastric outlet obstruction or ulcer perforation)
- Presence of esophageal / gastric varices
- aspirin or NSAID user
- Pregnancy
- Age \<18 or \>90
- Moribund patients, patients with severe liver or renal disease
- Known sensitivity to proton pump inhibitors
- Previous gastric surgery (except simple patch repair)
- Patient unable to give written consent
- Special population, e.g. prisoner, mentally disabled, investigators' student or employees
Key Trial Info
Start Date :
September 1 2005
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
September 1 2007
Estimated Enrollment :
20 Patients enrolled
Trial Details
Trial ID
NCT00471029
Start Date
September 1 2005
End Date
September 1 2007
Last Update
May 9 2007
Active Locations (1)
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1
Pamela Youde Nethersole Eastern Hospital
Hong Kong, China