Status:
COMPLETED
Normal Immunological Parameters Among Healthy Volunteers in Kambila, Mali
Lead Sponsor:
National Institute of Allergy and Infectious Diseases (NIAID)
Collaborating Sponsors:
University of Bamako
Conditions:
Malaria
Eligibility:
All Genders
18-55 years
Brief Summary
This study will determine the immune response to malaria infection in healthy volunteers compared with malaria patients. Malaria affects millions of people in Mali and Africa. It can cause fever, head...
Detailed Description
Malaria results in at least 2.7 million deaths per year, the majority among African children. The development of a vaccine against Plasmodium falciparum is regarded as a crucial step toward control o...
Eligibility Criteria
Inclusion
- INCLUSION CRITERIA:
- Age 18 - 55 years
- Resident of Kambila, Tieneguebougou or Kalifabougou
- Adequate venous access
- Willingness to allow blood samples to be stored and used for future studies of the immune response to malaria
- Ability to give informed consent and willingness to comply with study requirements and procedures
- EXCLUSION CRITERIA:
- Anemia (hemoglobin less than 11 g/dL).
- Currently taking antimalarials, corticosteroids or other immunosuppressants.
- Underlying heart disease, bleeding disorder, or other conditions that in the judgment of the Principal Investigator (PI) could increase the risk to the volunteer.
- Fever greater than or equal to 37.5 degrees Celsius or evidence of an acute infection.
- Current pregnancy, as determined by urine dipstick test for pregnancy.
- Participation in another clinical protocol that requires the administration of an experimental vaccine or experimental treatment.
Exclusion
Key Trial Info
Start Date :
August 1 2007
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
May 23 2022
Estimated Enrollment :
310 Patients enrolled
Trial Details
Trial ID
NCT00471302
Start Date
August 1 2007
End Date
May 23 2022
Last Update
June 1 2022
Active Locations (1)
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1
U Mali Faculty Med Pharmacy & Dentistry IRB #1
Bamako, Mali