Status:
COMPLETED
Dexamethasone Infusion in Community-acquired Pneumonia
Lead Sponsor:
St. Antonius Hospital
Conditions:
Pneumonia
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
The purpose of this study is to determine whether dexamethasone reduces the length of hospital stay in patient with a community-acquired pneumonia.
Detailed Description
Community-acquired pneumonia (CAP) is common and approximately 20 percent of all episodes of pneumonia result in hospitalization. It is the leading cause of community-acquired infection requiring ICU ...
Eligibility Criteria
Inclusion
- Patients aged 18 to 100 years with a community-acquired pneumonia.
- Criteria to determine a community-acquired pneumonia:
- Chest radiograph showing new opacities
- In combination with two of the following findings:
- Cough
- Production of sputum
- Temp \>38,0 °C or \<36,0 °C
- Audible abnormalities by chest examination compatible with pneumonia
- Leukocytosis (\>10.000 cells/mm3), leftward shift (\>10%) or leukopenia (\<4000 cells/mm3)
- CRP \> 15 mg/dl (three times upper limit of normal)
Exclusion
- o The following groups are excluded:
- Immunocompromised patients:
- Patients with a known congenital or achieved immunodeficiency.
- Patients who received chemotherapy less than 6 weeks ago.
- Patients who received corticosteroids in the last 6 weeks.
- Patients who received immunosuppressive medication in the last 6 weeks. (like cyclosporine, cyclofosfamide, azathioprine)
- Patients with COPD who are on systemic corticosteroids for COPD.
- Patients who require ICU treatment.
Key Trial Info
Start Date :
November 1 2007
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
September 1 2010
Estimated Enrollment :
300 Patients enrolled
Trial Details
Trial ID
NCT00471640
Start Date
November 1 2007
End Date
September 1 2010
Last Update
September 27 2010
Active Locations (2)
Enter a location and click search to find clinical trials sorted by distance.
1
Gelderse Vallei Ede
Ede, Gelderland, Netherlands
2
St Antonius Hosptial
Nieuwegein, Utrecht, Netherlands, 3430 EM