Status:
COMPLETED
Medical Implications of Coinfection With Malaria and Filariasis Parasites
Lead Sponsor:
National Institute of Allergy and Infectious Diseases (NIAID)
Conditions:
Malaria
Filariasis
Eligibility:
All Genders
1-20 years
Brief Summary
This study will examine the clinical, immunological and epidemiological effects of concurrent infections with P. falciparum and W. bancrofti or M. perstans (the parasites that cause malaria and filari...
Detailed Description
Residents of malaria-endemic regions are frequently exposed to a variety of other parasites concurrently with malarial parasites. In Mali, lymphatic filariasis due to Wuchereria bancrofti co-exists in...
Eligibility Criteria
Inclusion
- INCLUSION CRITERIA (Screening):
- Age 1 - 20 years
- Male or non-pregnant female
- Resident of Tien gu bougou or Bougoudiana
- EXCLUSION CRITERIA (Screening):
- History or clinical evidence of severe and/or chronic illness
- History of allergy to artesunate, amodiaquine, albendazole, praziquantel or mebendazole
- Plans to relocate outside the immediate vicinity of the village during the study period
- INCLUSION CRITERIA (Matched prospective study):
- Age 1 - 20 years
- Male or non-pregnant female
- Resident of Tien gu bougou or Bougoudiana
- EXCLUSION CRITERIA (Matched prospective study):
- History or clinical evidence of severe and/or chronic illness
- History of allergy to artesunate, amodiaquine, albendazole, praziquantel or mebendazole
- Plans to relocate outside the immediate vicinity of the village during the study period
- Hemoglobin less than or equal to 8 g/dL
- Symptoms of malaria with parasitemia greater than or equal to 100,000/microliters at enrollment
- Recent history or clinical evidence of prostration, bleeding, respiratory distress, seizures, coma or obtundation, jaundice, inability to drink, persistent vomiting
- INCLUSION CRITERIA: (Immunologic Extension Study)
- Age \> 10 years
- Male or non-pregnant female (by history)
- Resident of Tien gu bougou or Bougoudiana
- Willingness to allow storage of specimens for future research
- EXCLUSION CRITERIA: (Immunologic Extension Study)
- History or clinical evidence of severe and/or chronic illness
- Hemoglobin less than or equal to g/dL
- Positive pregnancy test
- Clinical malaria (symptoms of malaria plus any malaria parasites identified on thick smear)
Exclusion
Key Trial Info
Start Date :
May 7 2007
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
January 31 2012
Estimated Enrollment :
1039 Patients enrolled
Trial Details
Trial ID
NCT00471666
Start Date
May 7 2007
End Date
January 31 2012
Last Update
July 2 2017
Active Locations (1)
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1
Faculty of Medicine, Pharmacy and Odonto-Stomatology (FMPOS)
Bamako, Mali