Status:
COMPLETED
Dry Eye in Women With Turner Syndrome and Women With Premature Ovarian Failure
Lead Sponsor:
National Eye Institute (NEI)
Conditions:
Turner Syndrome
Ovarian Failure, Premature
Eligibility:
FEMALE
18+ years
Brief Summary
Premature ovarian failure (POF) is known to be associated with an increased risk of ocular surface disease (dry eye), likely due to the reduction of both estrogens and androgens seen in this condition...
Detailed Description
Premature ovarian failure (POF) is known to be associated with an increased risk of ocular surface disease (dry eye), likely due to the reduction of both estrogens and androgens seen in this condition...
Eligibility Criteria
Inclusion
- INCLUSION CRITERIA:
- Ability to understand and give informed consent.
- Meet the diagnostic criteria for TS (45, X0) or premature ovarian failure OR age matched control for study participant with TS or POF.
- For non Turner syndrome subjects only - Negative pregnancy test or post menopausal status for greater than or equal to 1 year.
- Karyotype of XO for TS subjects or XX for POF and age matched control subjects.
- EXCLUSION CRITERIA:
- Persons less than 18 years old.
- Persons with ophthalmic diseases associated with ocular surface disease.
- Hyperprolactinemia.
- Cushing s syndrome.
- Other endocrine disorders which impact sex steroid hormones.
- AIDS
- Pregnancy or lactation.
- For age matched control population ONLY- complaints of dry eye.
- For age matched control population ONLY- oral contraceptives or menopausal hormone therapy or any medications which alter sex hormone levels in the blood or chronic usage of medications that induce dry eye.
Exclusion
Key Trial Info
Start Date :
May 7 2007
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
November 13 2014
Estimated Enrollment :
72 Patients enrolled
Trial Details
Trial ID
NCT00471731
Start Date
May 7 2007
End Date
November 13 2014
Last Update
February 14 2018
Active Locations (1)
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1
National Institutes of Health Clinical Center, 9000 Rockville Pike
Bethesda, Maryland, United States, 20892