Status:
WITHDRAWN
Low Dose Apomorphine and Parkinsonism
Lead Sponsor:
Oregon Health and Science University
Collaborating Sponsors:
National Institute of Neurological Disorders and Stroke (NINDS)
Conditions:
Parkinson's Disease
Eligibility:
All Genders
35-85 years
Phase:
PHASE2
Brief Summary
The purpose of this study is to determine if low doses of apomorphine worsen the motor symptoms of Parkinson's disease.
Detailed Description
The goal of the study is to learn why some people with Parkinson's disease (PD) get worse right after taking PD medication such as carbidopa/levodopa or as the medication is wearing off. In this stud...
Eligibility Criteria
Inclusion
- Have idiopathic Parkinson's disease treated with levodopa and experiencing motor fluctuations
- Response to levodopa had to be documented by a 10 percent increase in finger or foot tapping speed
Exclusion
- Clinically significant cardiovascular, cerebrovascular, hepatic and renal diseases
- Psychosis
- Allergy to apomorphine or 5ht3 inhibitors
- Prolonged qt interval
- Pregnancy/breast-feeding
- Hemodynamic instability
- Severe nausea
- Alcohol/drug abuse
- Other unstable medical conditions
Key Trial Info
Start Date :
October 1 2005
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
May 1 2007
Estimated Enrollment :
Patients enrolled
Trial Details
Trial ID
NCT00472355
Start Date
October 1 2005
End Date
May 1 2007
Last Update
November 29 2018
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
Department of Neurology, Oregon Health and Science University, Mail Code OP32, 3181 SW Sam Jackson Park Road
Portland, Oregon, United States, 97239