Status:
COMPLETED
The Efficacy of Influenza Vaccine in Reducing Cardiovascular Events in Patients With Coronary Artery Diseases
Lead Sponsor:
Shahid Beheshti University of Medical Sciences
Conditions:
Coronary Artery Diseases
Myocardial Infarction
Eligibility:
All Genders
25+ years
Phase:
PHASE2
PHASE3
Brief Summary
Influenza vaccine reduces the cardiovascular events in post-myocardial infarction (MI) patients and in those with stable angina (SA).
Detailed Description
A connection between infectious processes and atherosclerosis is repeatedly reported \[1\]. Acute respiratory infection was found to be associated with myocardial infarction (MI) \[2,3\] and a number ...
Eligibility Criteria
Inclusion
- Patients with the diagnosis of acute, evolving or recent MI (after recovered the acute phase) as defined by:
- Typical rise and gradual fall (troponin) or more rapid rise and fall (CK-MB) of biochemical markers of myocardial necrosis with at least one of the following:
- Ischemic symptoms
- Development of pathologic Qwaves on the ECG
- ECG changes indicative of ischemia (ST segment elevation or depression); OR
- Coronary artery intervention (e.g., coronary angioplasty).
- Pathologic findings of an acute MI \[12\]
- Patients with stable angina pectoris and documented coronary artery stenosis (angiography).
Exclusion
- Any acute disease
- Chronic liver or kidney diseases
- Conditions accompanied by immunosuppression (like organ transplantation, HIV)
- Diagnosed malignancy
- Incubation with influenza vaccine within the past 5 years
- Any psychological disease that interferes with regular follow-up
- Congestive heart failure (Killip class IV)
- Unstable angina, and contradictions of vaccine incubation (like egg allergy).
Key Trial Info
Start Date :
January 1 2008
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
September 1 2008
Estimated Enrollment :
300 Patients enrolled
Trial Details
Trial ID
NCT00607178
Start Date
January 1 2008
End Date
September 1 2008
Last Update
January 22 2009
Active Locations (1)
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1
Shaheed Modarres Medical Center
Tehran, Tehran Province, Iran, 19814