Status:
COMPLETED
Brassica Vegetables or Indole-3-Carbinol in Treating Patients With PSA Recurrence After Surgery for Prostate Cancer
Lead Sponsor:
Vanderbilt University
Collaborating Sponsors:
National Cancer Institute (NCI)
Conditions:
Prostate Cancer
Eligibility:
MALE
18+ years
Phase:
NA
Brief Summary
RATIONALE: Eating a diet high in vegetables may lower the risk of some types of cancer. Brassica vegetables (such as cabbages, kale, broccoli, Brussels sprouts, and cauliflower) and indole-3-carbinol ...
Detailed Description
OBJECTIVES: * Determine the feasibility of Brassica vegetable intake and indole-3-carbinol supplement use in patients with prostate cancer with prostate-specific antigen (PSA) recurrence after prosta...
Eligibility Criteria
Inclusion
- Diagnosis of prostate cancer with PSA recurrence after prostatectomy
- PSA recurrence is defined as two consecutively rising PSA tests ≥ 8 weeks since the post-surgical nadir, with a minimal interval of 2 weeks between tests and at least 1 PSA test \> 0.4 ng/mL
Exclusion
- Life expectancy ≥ 9 months
- No predictors of poor adherence (e.g., erratic life-style, mental incompetence)
- PRIOR CONCURRENT THERAPY:
- See Disease Characteristics
- No other concurrent Brassica vegetable consumption \> 1 serving/day
- No other concurrent indole-3-carbinol supplements
- No endocrine or radiation treatment within past 4 weeks
- No other scheduled treatment during study intervention
- Concurrent prescription medications during the trial allowed
- At least 2 weeks since prior and no concurrent vitamin or herbal supplement use
- Patients refusing to stop non-study supplements will be asked to maintain constant use
Key Trial Info
Start Date :
March 1 2005
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
November 1 2010
Estimated Enrollment :
66 Patients enrolled
Trial Details
Trial ID
NCT00607932
Start Date
March 1 2005
End Date
November 1 2010
Last Update
April 27 2016
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