Status:
COMPLETED
The Early Recognition of Pulmonary Arterial Hypertension
Lead Sponsor:
Medical University of Graz
Conditions:
Pulmonary Arterial Hypertension
Eligibility:
All Genders
Phase:
NA
Brief Summary
The early detection of pulmonary arterial hypertension may help to improve prognosis of the disease. It is assumed that in the early stages of pulmonary arterial hypertension, pulmonary arterial press...
Detailed Description
Pulmonary arterial hypertension (PAH) is a rare, life-threatening disease. It is characterised by the elevation of pulmonary arterial pressure and pulmonary vascular resistance. A remodelling of small...
Eligibility Criteria
Inclusion
- Systemic sclerosis
- SLE
- Late corrected left-right shunt
- HIV Infection
- Splenectomy over 10 years
- Haemoglobinopathy and Thrombocytosis
- Ventriculo-atrial Shunt
- Liver cirrhosis/other portal Hypertension
- Anamnestic Aminorex or PhenFen abuse
- Close relatives of patients with IPAH
- Healthy controls
Exclusion
- Known PAH
- Severe lung or bronchial disease (FEV1 \<70% predicted)
- Systolic LV dysfunction (LVEF \<50%) or diastolic dysfunction (pulmonary arterial "wedge" pressure (PAWP) ≥15 mmHg)
- Valvular dysfunction \> Grad I (except of Tricuspidal- and Pulmonary insufficiency)
- Uncontrolled systemic arterial hypertension (rest \>150 mmHg systolic or 90 mmHg diastolic; exercise \>220 mmHg systolic)
- Uncontrolled ventricular arrythmia
- Uncontrolled supraventricular arrythmia
- Myocardial infarction within last 12 months
- Pulmonary embolism within last 12 months
- Significant change in therapy or larger operation within last 12 weeks
- Inability of performing exercise on cycle ergometer
Key Trial Info
Start Date :
April 1 2006
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
May 1 2009
Estimated Enrollment :
52 Patients enrolled
Trial Details
Trial ID
NCT00609349
Start Date
April 1 2006
End Date
May 1 2009
Last Update
January 12 2012
Active Locations (1)
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1
Medical University Graz, Division of Pulmonology
Graz, Styria, Austria, 8036